Western Blot (WB)
(Western Blot analysis of various cells using IRS-1 Polyclonal Antibody at dilution of 1:500.)
Rabbit IRS-1 Polyclonal Antibody | anti-IRS-1 antibody
IRS-1 Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of various cells using IRS-1 Polyclonal Antibody at dilution of 1:500.)
Western Blot (WB)
(Western Blot analysis of various cells using IRS-1 Polyclonal Antibody at dilution of 1:500.)
NCBI and Uniprot Product Information
Observed MW: 180130
NCBI Description
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Uniprot Description
IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q36
Cellular Component: caveola; cytoplasm; cytosol; intracellular membrane-bound organelle; nucleus; plasma membrane
Molecular Function: insulin receptor binding; insulin-like growth factor receptor binding; phosphoinositide 3-kinase binding; protein binding; protein kinase C binding; SH2 domain binding; signal transducer activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: activation of MAPKK activity; axon guidance; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; glucose homeostasis; innate immune response; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; lipid catabolic process; mammary gland development; MAPKKK cascade; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; nerve growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase activity; protein kinase B signaling cascade; Ras protein signal transduction; regulation of gene expression; response to insulin stimulus; response to peptide hormone stimulus; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway
Disease: Diabetes Mellitus, Noninsulin-dependent
Research Articles on IRS-1
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Product Notes
The IRS-1 irs1 (Catalog #AAA2536648) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IRS-1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IRS-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000. Researchers should empirically determine the suitability of the IRS-1 irs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRS-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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