Rabbit anti-Rat Iron Regulatory Protein Polyclonal Antibody | anti-Irp-1B antibody
Anti - Iron Regulatory Protein (IRP-1)
Gene Names
Irp-1B; 144037_at; C-Acon; cAcon; CG6342; DmelCG6342; IRP-1; IRP-1B; IRP1
Reactivity
Rat
Applications
ELISA
Purity
Serum
Synonyms
Iron Regulatory Protein; Polyclonal Antibody; Anti - Iron Regulatory Protein (IRP-1); Iron Regulatory Protein (IRP-1); anti-Irp-1B antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognized rat IRP-1. No significant sequence homology exist with IRP-2.
Purity/Purification
Serum
Form/Format
Supplied as a liquid, 0.09% sodium azide
Applicable Applications for anti-Irp-1B antibody
ELISA (EIA)
Application Notes
ELISA: 1:100,000 using 50-100ng control peptide/well.
Immunogen
Synthetic peptide corresponding to 20aa within the N-Terminal of rat IRP-1, conjugated to KLH. Species Sequence Homology: mouse; 94%, human and rabbit; 89%
Grade
Serum
Control Peptide
Iron Regulatory Protein, Rat, Control Peptide (IRP-1).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-Irp-1B antibody
Elemental iron is required for a variety of normal cellular functions and vital for proper growth and development. However, natural iron is quite insoluble and excess iron is harmful, since it can catalyze the formation of potentially damaging reactive oxygen species. Humans also have very limited capacity to excrete iron. Therefore, cells have developed mechanisms to improve solubility of iron and to control intracellular iron levels at the point of absorption in the intestine and other tissue. Several proteins including Ferritin, transferrin (Tf), transferrin receptors (TfRs), and iron regulatory proteins (IRPs), iron transporter (NRMAP2/DMT1/DCT1) etc play a key role in iron metabolism. Some genes involved in iron-metabolism are associated with genetic disorders such as Friedreich's Ataxia (Frataxin), genetic hemochromatosis (HFE), and Sex-linked anemia (Hephaestin).
Product Categories/Family for anti-Irp-1B antibody
References
• 1. Yu, Y., et al., JBC 267, 19005 (1992).
• 2. Phillipot, C.C., et al., Nucl. Acid. Res. 19: 6333 (1991).
• 3. Hirling, H., et al., Nucl. Acid. Res. 20: 33 (1992).
• 4. Rouault, T.A., et al., PNAS 87: 7958 (1990).
• 5. Kaptain, S., et al., PNAS 88: 10109 (1991).
• 6. Cairo, G., et al., Biochem. J. 352: 241 (2000, review).
• 2. Phillipot, C.C., et al., Nucl. Acid. Res. 19: 6333 (1991).
• 3. Hirling, H., et al., Nucl. Acid. Res. 20: 33 (1992).
• 4. Rouault, T.A., et al., PNAS 87: 7958 (1990).
• 5. Kaptain, S., et al., PNAS 88: 10109 (1991).
• 6. Cairo, G., et al., Biochem. J. 352: 241 (2000, review).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
iron regulatory protein 1B
NCBI Official Synonym Full Names
Iron regulatory protein 1B
NCBI Official Symbol
Irp-1B
NCBI Official Synonym Symbols
144037_at; C-Acon; cAcon; CG6342; DmelCG6342; IRP-1; IRP-1B; IRP1
NCBI Protein Information
CG6342 gene product from transcript CG6342-RA; iron regulatory protein 1B; CG6342-PA; Irp-1B-PA; cytoplasmic aconitase; cytosolic aconitase
Similar Products
Product Notes
The Irp-1B (Catalog #AAA616236) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti - Iron Regulatory Protein (IRP-1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Iron Regulatory Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:100,000 using 50-100ng control peptide/well. Researchers should empirically determine the suitability of the Irp-1B for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Iron Regulatory Protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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