Rabbit anti-Human IRF2BP2 Polyclonal Antibody | anti-IRF2BP2 antibody

Rabbit Polyclonal to Human IRF2BP2

Cat. Num. AAA247218

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: IRF2BP2; Polyclonal Antibody; Rabbit Polyclonal to Human IRF2BP2; Anti-IRF2BP2 Antibody (N-Terminus) IHC-plus; IRF-2-binding protein 2; IRF-2BP2; Human IRF2BP2; anti-IRF2BP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 587

• Applicable Applications for anti-IRF2BP2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: An 17 amino acid peptide near the amino terminus of human IRF2BP2.
• Immunogen Type: Synthetic peptide
• Immunogen: IRF2BP2 antibody was raised against an 17 amino acid peptide near the amino terminus of human IRF2BP2.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-IRF2BP1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-IRF2BP1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 116734704
• NCBI GeneID: 359948
• NCBI Accession #: NP_892017.2
• NCBI GenBank Nucleotide #: NM_182972.2
• UniProt Accession #: Q7Z5L9; Q6P083; Q7Z5L8; Q8N351; Q8WUH8; B1AM35; B1AM36
• Molecular Weight: 17,139 Da
• NCBI Official Full Name: interferon regulatory factor 2-binding protein 2 isoform A
• NCBI Official Synonym Full Names: interferon regulatory factor 2 binding protein 2
• NCBI Official Symbol: IRF2BP2
• NCBI Protein Information: interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2
• UniProt Protein Name: Interferon regulatory factor 2-binding protein 2
• Protein Family: Interferon regulatory factor 2-binding protein
• UniProt Gene Name: IRF2BP2
• UniProt Synonym Gene Names: IRF-2-binding protein 2; IRF-2BP2
• UniProt Entry Name: I2BP2_HUMAN

NCBI Description

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

IRF2BP2: Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. Belongs to the IRF2BP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q42.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: metal ion binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent