Rabbit anti-Human, Mouse IQGAP2 Polyclonal Antibody | anti-IQGAP2 antibody

IQGAP2, CT (IQGAP2, Ras GTPase-activating-like protein IQGAP2) (MaxLight 750)

Cat. Num. AAA6310804

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IQGAP2; Polyclonal Antibody; CT (IQGAP2; Ras GTPase-activating-like protein IQGAP2) (MaxLight 750); Ras GTPase-activating-like protein IQGAP2; anti-IQGAP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-IQGAP2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: IQGAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1435-1463 amino acids from the C-terminal region of human IQGAP2.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-IQGAP2 antibody

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility.

Product Categories/Family for anti-IQGAP2 antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Van Laer, L., et al. Eur. J. Hum. Genet. 18(6):685-693(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Jin, S.H., et al. Int. J. Cancer 122(5):1040-1046(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 116089337
• NCBI GeneID: 10788
• NCBI Accession #: NP_006624.2
• NCBI GenBank Nucleotide #: NM_006633.3
• UniProt Accession #: Q13576; A8K4V1; B7Z8A4; J3KR91
• Molecular Weight: 122,806 Da
• NCBI Official Full Name: ras GTPase-activating-like protein IQGAP2 isoform 1
• NCBI Official Synonym Full Names: IQ motif containing GTPase activating protein 2
• NCBI Official Symbol: IQGAP2
• NCBI Protein Information: ras GTPase-activating-like protein IQGAP2
• UniProt Protein Name: Ras GTPase-activating-like protein IQGAP2
• Protein Family: Ras GTPase-activating-like protein
• UniProt Gene Name: IQGAP2
• UniProt Entry Name: IQGA2_HUMAN

NCBI Description

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]

Uniprot Description

IQGAP2: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: filamentous actin; microtubule; microvillus; cell surface; lamellipodium; cytoplasm; actin cytoskeleton; filopodium

Molecular Function: calmodulin binding; actin filament binding; phosphatidylinositol-3,4,5-triphosphate binding; Rho GTPase binding; Rac GTPase binding; actin binding; GTPase inhibitor activity

Biological Process: small GTPase mediated signal transduction; negative regulation of catalytic activity; signal transduction