Western Blot (WB)
(Western blot analysis of extracts from HT-29 cells, using IP3KC antibody.)
Rabbit anti-Human IP3KC Polyclonal Antibody | anti-IP3KC antibody
IP3KC Antibody
Western Blot (WB)
(Western blot analysis of extracts from HT-29 cells, using IP3KC antibody.)
Western Blot (WB)
(Western blot analysis of extracts from HT-29 cells, using IP3KC antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
Uniprot Description
ITPKC: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Defects in ITPKC are a cause of Kawasaki disease (KWD); also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries. Belongs to the inositol phosphokinase (IPK) family.
Protein type: Kinase, lipid; EC 2.7.1.127; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: nucleus; cytosol
Molecular Function: calmodulin binding; inositol trisphosphate 3-kinase activity; ATP binding
Biological Process: inositol phosphate metabolic process; phosphorylation
Disease: Kawasaki Disease
Research Articles on IP3KC
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Product Notes
The IP3KC itpkc (Catalog #AAA9401045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IP3KC Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IP3KC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the IP3KC itpkc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IP3KC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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