Western Blot (WB)
Rabbit anti-Mouse Interleukin 6, IL-6 Polyclonal Antibody | anti-IL-6 antibody
Anti-Interleukin 6, IL-6 antibody
Reactivity
Mouse
Applications
Western Blot, ELISA
Purity
Immunogen affinity purified
Synonyms
Interleukin 6; IL-6; Polyclonal Antibody; Anti-Interleukin 6; IL-6 antibody; Polyclonal Anti- Interleukin 6; anti-IL-6 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified
Form/Format
Liquid
Applicable Applications for anti-IL-6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB (1:1000); ELISA (1:5000-10,000)
Immunogen
A synthetic peptide (conjugated to KLH) corresponding to the region of mouse IL-6.
Storage Buffer
In TBS (pH7.4), no preservative, sterile filtered
Storage Buffer
In TBS (pH7.4), no preservative, sterile filtered.
Preparation and Storage
Store at 4 degree C after thawing (1 week). Aliquot and store at -20 degree C for long term (at least one year). Avoid repeated freeze and thaw cycles
Western Blot (WB)
Western Blot (WB)
Related Product Information for anti-IL-6 antibody
IL-6 is an immunoregulatory cytokine that activates a cell surface signaling assembly composed of IL6, IL6RA, and the shared signaling receptor gp130. [1] It belongs to the IL-6 superfamily. And It is secreted by T cells and macrophages to stimulate immune response. IL-6 is one of the most important mediators of fever and of the acute phase response. It is capable of crossing the blood brain barrier[2] and initiating synthesis of PGE2 in the hypothalamus, thereby changing the body's temperature setpoint. It also plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation.[3]
References
1. Boulanger, M. J., Chow, D., Brevnova, E. E., Garcia, K. C. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300: 2101-2104, 2003. 2. Banks WA, Kastin AJ, Gutierrez EG (September 1994). "Penetration of interleukin-6 across the murine blood-brain barrier". Neurosci. Lett. 179 (1-2): 53-6. 3. Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S., Nakajima, K., Koyama, K., Iwamatsu, A., Tsunasawa, S., Sakiyama, F., Matsui, H., Takahara, Y., Taniguchi, T., Kishimoto, T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76, 1986.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
23,953 Da
NCBI Official Full Name
interleukin-6
NCBI Official Symbol
IL6
NCBI Protein Information
interleukin-6; IL-6; interleukin-6 protein
UniProt Protein Name
Interleukin-6
UniProt Gene Name
IL6
UniProt Synonym Gene Names
IL-6
UniProt Entry Name
IL6_PIG
Uniprot Description
Function: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the IL-6 superfamily.
Research Articles on IL-6
Similar Products
Product Notes
The IL-6 il6 (Catalog #AAA355074) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Interleukin 6, IL-6 antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 6, IL-6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB (1:1000); ELISA (1:5000-10,000). Researchers should empirically determine the suitability of the IL-6 il6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 6, IL-6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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