Rabbit anti-Human Interleukin 2 Receptor Gamma (IL2Rg) Polyclonal Antibody | anti-IL2Rg antibody
FITC-Linked Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg)
Immunohistochemistry: 5-20 ug/mL;1:25-100
Immunocytochemistry: 5-20 ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Uniprot Description
IL2RG: Common subunit for the receptors for a variety of interleukins. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell- negative (XSCID); also known as agammaglobulinemia Swiss type. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell- mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID). XCID is a less severe form of X-linked immunodeficiency with a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. Belongs to the type I cytokine receptor family. Type 5 subfamily.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: external side of plasma membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: interleukin-2 binding; interleukin-2 receptor activity; interleukin-4 receptor activity; interleukin-7 receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: immune response; MAPKKK cascade
Disease: Combined Immunodeficiency, X-linked; Severe Combined Immunodeficiency, X-linked
Research Articles on IL2Rg
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Product Notes
The IL2Rg il2rg (Catalog #AAA2056088) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FITC-Linked Polyclonal Antibody to Interleukin 2 Receptor Gamma (IL2Rg) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 2 Receptor Gamma (IL2Rg) can be used in a range of immunoassay formats including, but not limited to, Western blotting (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); IF. Western blotting: 0.5-2 ug/mL;1:250-1000 Immunohistochemistry: 5-20 ug/mL;1:25-100 Immunocytochemistry: 5-20 ug/mL;1:25-100 Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the IL2Rg il2rg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 2 Receptor Gamma (IL2Rg), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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