Western Blot (WB)
Rabbit anti-Human, mouse Interleukin 13 receptor, alpha 1, IL13Ralpha1 Polyclonal Antibody | anti-IL13Ralpha1 antibody
Anti-Interleukin 13 receptor, alpha 1, IL13Ralpha1 antibody
Western Blot (WB)
Western Blot (WB)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
Subunit structure: Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1. Ref.9 Ref.10
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.
Sequence similarities: Belongs to the type I cytokine receptor family. Type 5 subfamily.
Research Articles on IL13Ralpha1
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Product Notes
The IL13Ralpha1 il13ra1 (Catalog #AAA355052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Interleukin 13 receptor, alpha 1, IL13Ralpha1 antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 13 receptor, alpha 1, IL13Ralpha1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1:500-1000). Researchers should empirically determine the suitability of the IL13Ralpha1 il13ra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 13 receptor, alpha 1, IL13Ralpha1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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