Knockout Validation
(Knockout Validation: Lane 1: Wild-type Raji cell lysate; Lane 2: IL1R1 knockout Raji cell lysate; Predicted MW: 65kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human IL1R1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Interleukin 1 Receptor Type I (IL1R1) Polyclonal Antibody | anti-IL1R1 antibody
Cy3-Linked Polyclonal Antibody to Interleukin 1 Receptor Type I (IL1R1)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Raji cell lysate; Lane 2: IL1R1 knockout Raji cell lysate; Predicted MW: 65kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human IL1R1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Raji cell lysate; Lane 2: IL1R1 knockout Raji cell lysate; Predicted MW: 65kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human IL1R1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Uniprot Description
IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.
Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 2q11.2-q12.1
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: interleukin-1 receptor activity; platelet-derived growth factor receptor binding; protein binding; signal transducer activity; transmembrane receptor activity
Biological Process: cell surface receptor linked signal transduction; immune response
Research Articles on IL1R1
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Product Notes
The IL1R1 il1r1 (Catalog #AAA2036596) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to Interleukin 1 Receptor Type I (IL1R1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interleukin 1 Receptor Type I (IL1R1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the IL1R1 il1r1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interleukin 1 Receptor Type I (IL1R1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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