Rabbit integrin beta 1 binding protein 1 Polyclonal Antibody | anti-ITGB1BP1 antibody
Rabbit anti-human integrin beta 1 binding protein 1 polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. [provided by RefSeq, Jul 2008]
Uniprot Description
ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 2p25.2
Cellular Component: ruffle; cytoskeleton; focal adhesion; membrane; lamellipodium; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: integrin binding; protein binding; GDP-dissociation inhibitor activity; protein complex binding; protein kinase binding; protein transporter activity
Biological Process: integrin activation; cell-matrix adhesion; receptor clustering; negative regulation of cell proliferation; regulation of cell adhesion mediated by integrin; protein transport; positive regulation of focal adhesion formation; biomineral formation; positive regulation of cell proliferation; positive regulation of stress fiber formation; negative regulation of protein binding; regulation of blood vessel size; cell differentiation; positive regulation of Notch signaling pathway; integrin-mediated signaling pathway; Notch signaling pathway; substrate-bound cell migration, cell release from substrate; cell migration; transcription, DNA-dependent; activation of protein kinase B; negative regulation of focal adhesion formation; lumen formation; positive regulation of protein kinase B signaling cascade; blood vessel endothelial cell proliferation during sprouting angiogenesis; positive regulation of cell division; myoblast migration; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter
Research Articles on ITGB1BP1
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Product Notes
The ITGB1BP1 itgb1bp1 (Catalog #AAA712876) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human integrin beta 1 binding protein 1 polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's integrin beta 1 binding protein 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the ITGB1BP1 itgb1bp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "integrin beta 1 binding protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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