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Goat anti-Mouse Insulin-Like Growth Factor Binding Protein-Like 1 Polyclonal Antibody | anti-IGFBPL1 antibody

Insulin-Like Growth Factor Binding Protein-Like 1 (IGFBP-L1, IGFBP-rP4)

Gene Names
IGFBPL1; IGFBP-RP4; bA113O24.1
Reactivity
Mouse
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity Purified
Purified by mouse IGFBP-L1 affinity chromatography.
Synonyms
Insulin-Like Growth Factor Binding Protein-Like 1; Polyclonal Antibody; Insulin-Like Growth Factor Binding Protein-Like 1 (IGFBP-L1; IGFBP-rP4); Anti -Insulin-Like Growth Factor Binding Protein-Like 1 (IGFBP-L1; anti-IGFBPL1 antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes mouse IGFBP-L1. (aa 18-270) Cross-reactivity
Purity/Purification
Affinity Purified
Purified by mouse IGFBP-L1 affinity chromatography.
Form/Format
Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitute with 0.5ml sterile PBS
Applicable Applications for anti-IGFBPL1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Suitable for use in Western blot, Immunohistochemistry, and Direct ELISA., , Recommended Dilutions:, Western Blot: 0.1-0.2ug/ml. The detection limit is ~2 ng/lane and 5 ng/lane under non-reducing and reducing conditions, respectively., Immunohistochemistry: 10ug/ml detects IGFBP-L1 in cryosections of E13.5 mouse brain. Tissue was fixed overnight in 4% PFA+14% picric acid in PBS at 4 degree C. Sections were blocked with 10% donkey serum and 0.1% Triton in 1% BSA in PBS for 45 minutes at RT. After, blocking, sections were incubated with primary antibody for 3 hours at RT followed by NorthernLightsTM 557 donkey anti-goat lgG at RT for 1 hour. Between each step, sections were, washed with 0.1% BSA in PBS., Direct ELISA: 0.5-1.0ug/ml. The detection limit is ~0.5 ng/well., Optimal dilutions to be determined by the researcher., , Storage and Stability:, Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
NS0-derived recombinant rat rmIGFBP-L1.
Preparation and Storage
-20 degree C
Related Product Information for anti-IGFBPL1 antibody
Insulin-like Growth Factor Binding Protein-Like 1 (also IGFBP-rP4) is a secreted member of the IGFBP family of proteins. Based on human, mature mouse IGFBP-L1 is a 251 amino acid (aa), 38kD glycoprotein. It contains an N-terminal IGFBP motif (aa 53-68), a kazal-type serine protease inhibitor region (aa 83-143) and a C-terminal Ig-like domain (aa 161-237). IGFBP-L1 is expressed in brain and testis and may be a tumor suppressor, possibly through the induction of apoptosis.
Product Categories/Family for anti-IGFBPL1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
29,005 Da
NCBI Official Full Name
insulin-like growth factor-binding protein-like 1
NCBI Official Synonym Full Names
insulin-like growth factor binding protein-like 1
NCBI Official Symbol
IGFBPL1
NCBI Official Synonym Symbols
IGFBP-RP4; bA113O24.1
NCBI Protein Information
insulin-like growth factor-binding protein-like 1; OTTHUMP00000021398; IGFBP-related protein 10; insulin-like growth factor-binding-related protein 4; insulin-like growth factor binding protein related protein 4
UniProt Protein Name
Insulin-like growth factor-binding protein-like 1
UniProt Gene Name
IGFBPL1
UniProt Synonym Gene Names
IGFBPRP4
UniProt Entry Name
IBPL1_HUMAN

Uniprot Description

IGFBPL1: IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors. May be a putative tumor suppressor protein.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p13.1

Cellular Component: extracellular region

Molecular Function: insulin-like growth factor binding

Biological Process: regulation of cell growth

Research Articles on IGFBPL1

Similar Products

Product Notes

The IGFBPL1 igfbpl1 (Catalog #AAA616690) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Insulin-Like Growth Factor Binding Protein-Like 1 (IGFBP-L1, IGFBP-rP4) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Insulin-Like Growth Factor Binding Protein-Like 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western blot, Immunohistochemistry, and Direct ELISA.,, Recommended Dilutions:, Western Blot: 0.1-0.2ug/ml. The detection limit is ~2 ng/lane and 5 ng/lane under non-reducing and reducing conditions, respectively., Immunohistochemistry: 10ug/ml detects IGFBP-L1 in cryosections of E13.5 mouse brain. Tissue was fixed overnight in 4% PFA+14% picric acid in PBS at 4 degree C. Sections were blocked with 10% donkey serum and 0.1% Triton in 1% BSA in PBS for 45 minutes at RT. After, blocking, sections were incubated with primary antibody for 3 hours at RT followed by NorthernLightsTM 557 donkey anti-goat lgG at RT for 1 hour. Between each step, sections were, washed with 0.1% BSA in PBS., Direct ELISA: 0.5-1.0ug/ml. The detection limit is ~0.5 ng/well., Optimal dilutions to be determined by the researcher.,, Storage and Stability:, Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Researchers should empirically determine the suitability of the IGFBPL1 igfbpl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Insulin-Like Growth Factor Binding Protein-Like 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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