Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Insulin Like Growth Factor 2 Receptor (IGF2R) Polyclonal Antibody | anti-IGF2R antibody
Polyclonal Antibody to Insulin Like Growth Factor 2 Receptor (IGF2R)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-VQI SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY YLRVCGKLSS DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG LLKMNYTGGD TCHKVYQRST TIYFYCDRTT QKPVFLKETS DCSYMFEWRT QYACPPFNVT ECSVQ
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded brain tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin- embedded brain tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Heart Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Heart Tissue))
NCBI and Uniprot Product Information
Uniprot Description
IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.
Protein type: Membrane protein, integral; Receptor, misc.; Vesicle
Chromosomal Location of Human Ortholog: 17 A1|17 8.64 cM
Cellular Component: cell surface; clathrin coat; cytoplasm; early endosome; endocytic vesicle; endosome; extracellular exosome; extracellular space; focal adhesion; Golgi apparatus; integral component of membrane; late endosome; lysosome; membrane; nuclear envelope lumen; nucleus; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle
Molecular Function: enzyme binding; G-protein alpha-subunit binding; G-protein coupled receptor activity; identical protein binding; insulin-like growth factor binding; insulin-like growth factor II binding; mannose binding; phosphoprotein binding; protein binding; retinoic acid binding; transporter activity
Biological Process: G-protein coupled receptor signaling pathway; liver development; positive regulation of apoptosis; regulation of apoptosis; response to retinoic acid; transport
Research Articles on IGF2R
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Product Notes
The IGF2R igf2r (Catalog #AAA2005046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Insulin Like Growth Factor 2 Receptor (IGF2R) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Insulin Like Growth Factor 2 Receptor (IGF2R) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the IGF2R igf2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-VQI SPQATGNGSL SILYVNGDRC GDQRFSTRIV FECAQTSGSP MFQFVNNCEY VFVWRTVEAC PVIREEGDNC QVKDPRHGNL YDLKPLGLND TIVSVGEYTY YLRVCGKLSS DVCSAHDGSK AVSSCQEKKG PQGFQKVAGL LSQKLTFENG LLKMNYTGGD TCHKVYQRST TIYFYCDRTT QKPVFLKETS DCSYMFEWRT QYACPPFNVT ECSVQ. It is sometimes possible for the material contained within the vial of "Insulin Like Growth Factor 2 Receptor (IGF2R), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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