Rabbit anti-Human, Mouse INO80 Polyclonal Antibody | anti-INO80 antibody
INO80 Antibody
Gene Names
INO80; INOC1; INO80A; hINO80
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
INO80; Polyclonal Antibody; INO80 Antibody; DNA helicase INO80; hINO80; homolog of yeast INO80; INO80 complex subunit A; INO80 homolog; INO80_HUMAN; INO80A; INOC1; KIAA1259; Putative DNA helicase INO80 complex homolog 1; anti-INO80 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
INO80 Antibody detects endogenous levels of total INO80.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-INO80 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
The DBINO region is involved in binding to DNA. Belongs to the SNF2/RAD54 helicase family.
Subunit Structure
Component of the chromatin remodeling INO80 complex; three different complex modules assemble on different domains of INO80. Interacts with DDB1. Interacts with transcriptional repressor protein YY1; the interaction recruits the INO80 complex to YY1 target genes. Interacts with YY1AP1. Interacts with tubulin alpha.
Tissue Specificity
According to widely expressed. According to specifically expressed in brain, liver and pancreas.
Function
ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Note
Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-INO80 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
176,753 Da
NCBI Official Full Name
DNA helicase INO80
NCBI Official Synonym Full Names
INO80 complex subunit
NCBI Official Symbol
INO80
NCBI Official Synonym Symbols
INOC1; INO80A; hINO80
NCBI Protein Information
DNA helicase INO80; INO80 homolog; homolog of yeast INO80; INO80 complex subunit A; putative DNA helicase INO80 complex homolog 1
UniProt Protein Name
DNA helicase INO80
Protein Family
UniProt Gene Name
INO80
UniProt Synonym Gene Names
INO80A; INOC1; KIAA1259; hINO80
UniProt Entry Name
INO80_HUMAN
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Product Notes
The INO80 ino80 (Catalog #AAA9629158) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INO80 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's INO80 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the INO80 ino80 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INO80, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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