Rabbit ING5 Polyclonal Antibody | anti-ING5 antibody

ING5 Rabbit Polyclonal

Cat. Num. AAA7600548

• Gene Names: ING5; p28ING5
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ING5; Polyclonal Antibody; ING5 Rabbit Polyclonal; anti-ING5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 240

• Applicable Applications for anti-ING5 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Inhibitor of growth family, member 5
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS7600548 (ING5 antibody) at dilution of 1:100)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7600548 (ING5 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 18644730
• NCBI GeneID: 84289
• NCBI Accession #: NP_115705.2
• NCBI GenBank Nucleotide #: NM_032329.4
• Molecular Weight: 25,932 Da
• NCBI Official Full Name: inhibitor of growth protein 5
• NCBI Official Synonym Full Names: inhibitor of growth family member 5
• NCBI Official Symbol: ING5
• NCBI Official Synonym Symbols: p28ING5
• NCBI Protein Information: inhibitor of growth protein 5
• UniProt Protein Name: Inhibitor of growth protein 5
• Protein Family: Inhibitor of growth protein
• UniProt Gene Name: ING5
• UniProt Entry Name: ING5_HUMAN

NCBI Description

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

ING5: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Belongs to the ING family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: nucleoplasm; nucleus

Molecular Function: chromatin binding; methylated histone residue binding; protein binding; zinc ion binding

Biological Process: DNA replication; negative regulation of cell proliferation; negative regulation of growth; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; protein amino acid acetylation; transcription, DNA-dependent