Rabbit anti-Human IMMP2L Polyclonal Antibody | anti-IMMP2L antibody

IMMP2L Antibody

Cat. Num. AAA7043970

• Gene Names: IMMP2L; IMP2; IMP2-LIKE; IMMP2L-IT1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: IMMP2L; Polyclonal Antibody; IMMP2L Antibody; Mitochondrial inner membrane protease subunit 2; IMP2-like protein; anti-IMMP2L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 175

• Applicable Applications for anti-IMMP2L antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Mitochondrial inner membrane protease subunit 2 protein (N-100AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-164660 / sc-164662
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human melanoma MBS7043970 at dilution 1:100)

Related Product Information for anti-IMMP2L antibody

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

NCBI and Uniprot Product Information

• NCBI GI #: 347446661
• NCBI GeneID: 83943
• NCBI Accession #: NP_001231535.1
• NCBI GenBank Nucleotide #: NM_001244606.1
• UniProt Accession #: Q96T52; Q75MF1; Q75MN9; Q75MP0; Q75MS5; Q75MS8; Q96HJ2
• Molecular Weight: 12,259 Da
• NCBI Official Full Name: mitochondrial inner membrane protease subunit 2
• NCBI Official Synonym Full Names: inner mitochondrial membrane peptidase subunit 2
• NCBI Official Symbol: IMMP2L
• NCBI Official Synonym Symbols: IMP2; IMP2-LIKE; IMMP2L-IT1
• NCBI Protein Information: mitochondrial inner membrane protease subunit 2
• UniProt Protein Name: Mitochondrial inner membrane protease subunit 2
• UniProt Gene Name: IMMP2L
• UniProt Entry Name: IMP2L_HUMAN

NCBI Description

This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]

Uniprot Description

IMMP2L: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO. Defects in IMMP2L may be a cause of Gilles de la Tourette syndrome (GTS). GTS is a neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. Belongs to the peptidase S26 family. IMP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC 3.4.21.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31

Molecular Function: peptidase activity; serine-type endopeptidase activity

Biological Process: mitochondrial protein processing; mitochondrial respiratory chain complex assembly; signal peptide processing