Rabbit anti-Human, Mouse IL9R Polyclonal Antibody | anti-IL9R antibody

IL9R, ID (IL9R, Interleukin-9 receptor, CD129) (MaxLight 490)

Cat. Num. AAA6310306

• Gene Names: IL9R; CD129; IL-9R
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: IL9R; Polyclonal Antibody; ID (IL9R; Interleukin-9 receptor; CD129) (MaxLight 490); CD129; anti-IL9R antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IL9R. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-IL9R antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 170-199 in the central region of human IL9R, UniProt Accession: Q01113.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in A549 cell line lysates (35ug/lane) usingMBS644701. This demonstrates that MBS644701 detected the IL9R protein (arrow).)

Western Blot (WB)

(Western Blot analysis in mouse liver tissue lysates (35ug/lane) usingMBS644701. This demonstrates that MBS644701 detected the IL9R protein (arrow).)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue using MBS644701 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS644701 for immunohistochemistry.)

Product Categories/Family for anti-IL9R antibody

Antibodies; CD Markers

References

1. Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010). 2. McCanlies, E.C., et al. J. Occup. Environ. Med. 52(7):680-684(2010). 3. Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010). 4. Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010). 5. Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 29171682
• NCBI GeneID: 3581
• NCBI Accession #: NP_002177.2
• NCBI GenBank Nucleotide #: NM_002186.2
• UniProt Accession #: Q01113; Q14634; Q8WWU1; Q96TF0; B9ZVT0
• Molecular Weight: 57,147 Da
• NCBI Official Full Name: interleukin-9 receptor isoform 1
• NCBI Official Synonym Full Names: interleukin 9 receptor
• NCBI Official Symbol: IL9R
• NCBI Official Synonym Symbols: CD129; IL-9R
• NCBI Protein Information: interleukin-9 receptor; IL-9 receptor
• UniProt Protein Name: Interleukin-9 receptor
• Protein Family: Interleukin-9 receptor
• UniProt Gene Name: IL9R
• UniProt Synonym Gene Names: IL-9 receptor; IL-9R
• UniProt Entry Name: IL9R_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

IL9R: This is a receptor for interleukin-9. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: interleukin-9 binding; interleukin-9 receptor activity

Biological Process: cell proliferation; signal transduction; positive regulation of cell growth