Western Blot (WB)
(IL23R Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the IL23R antibody detected the IL23R protein (arrow).)
Rabbit anti-Human IL23R Polyclonal Antibody | anti-IL23R antibody
IL23R, CT (IL23R, Interleukin-23 receptor)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(IL23R Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the IL23R antibody detected the IL23R protein (arrow).)
Western Blot (WB)
(IL23R Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the IL23R antibody detected the IL23R protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Ref.1
Subunit structure: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3. Ref.1
Subcellular location: Cell membrane; Single-pass type I membrane protein Ref.1.
Tissue specificity: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. Ref.1 Ref.2
Post-translational modification: Phosphorylated in response to IL23. Ref.1
Involvement in disease: Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5 Ref.7Psoriasis 7 (PSORS7) [MIM:605606]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 2 fibronectin type-III domains.
Sequence caution: The sequence AAH16829.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAH70408.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAI22679.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on IL23R
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Product Notes
The IL23R il23r (Catalog #AAA648988) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL23R, CT (IL23R, Interleukin-23 receptor) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL23R can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the IL23R il23r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL23R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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