Goat IL10 Polyclonal Antibody | anti-IL10 antibody

IL10 Polyclonal Antibody

Cat. Num. AAA448142

• Gene Names: IL10; CSIF; TGIF; GVHDS; IL-10; IL10A
• Reactivity: Human, Rat, Mouse, Canine, Monkey proteins
• Applications: Western Blot
• Purity: Epitope Affinity Purified
• Synonyms: IL10; Polyclonal Antibody; IL10 Polyclonal Antibody; Interleukin 10; anti-IL10; CSIF; GVHDS; IL-10; interleukin 10; IL10A; TGIF antibody; anti-IL10 antibody

• Host: Goat
• Reactivity: Human, Rat, Mouse, Canine, Monkey proteins
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Detects endogenous levels of total IL10 by Western blot in whole cell and tissue lysates.
• Purity/Purification: Epitope Affinity Purified
• Form/Format: Supplied as a 100 ul (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide.
• Sequence Length: 178

• Applicable Applications for anti-IL10 antibody: Western Blot (WB)
• Application Notes: WB: 1:250-1:5,000
• Immunogen: Purified recombinant human IL10 produced in E Coli.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 C for long-term storage. Store at 2-8 C for up to one month.; The antibody solution should be gently mixed before use.; Avoid freeze/thaw cycles.

Reactivity Chart

Wester Blot (WB)

Related Product Information for anti-IL10 antibody

Goat polyclonal to IL10. IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. It is involved in inflammation and immunoregulation. It down-regulates the expression of MHC class II antigens and Th1 cytokines on macrophages. It also enhances B cell survival, proliferation, and antibody production.

NCBI and Uniprot Product Information

• NCBI GI #: 10835141
• NCBI GeneID: 3586
• NCBI Accession #: NP_000563.1
• NCBI GenBank Nucleotide #: NM_000572.2
• UniProt Accession #: P22301
• Molecular Weight: 20,517 Da
• NCBI Official Full Name: interleukin-10
• NCBI Official Synonym Full Names: interleukin 10
• NCBI Official Symbol: IL10
• NCBI Official Synonym Symbols: CSIF; TGIF; GVHDS; IL-10; IL10A
• NCBI Protein Information: interleukin-10
• UniProt Protein Name: Interleukin-10
• Protein Family: Interleukin
• UniProt Gene Name: IL10
• UniProt Synonym Gene Names: IL-10; CSIF

NCBI Description

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

Uniprot Description

IL10: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family.

Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; extracellular space

Molecular Function: protein binding

Biological Process: cell-cell signaling; hemopoiesis; inflammatory response; leukocyte chemotaxis; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of cytokine secretion during immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-1 production; negative regulation of interleukin-12 production; negative regulation of interleukin-18 production; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of membrane protein ectodomain proteolysis; negative regulation of MHC class II biosynthetic process; negative regulation of mitotic cell cycle; negative regulation of tumor necrosis factor production; positive regulation of B cell apoptosis; positive regulation of cytokine secretion; positive regulation of heterotypic cell-cell adhesion; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; receptor biosynthetic process; regulation of gene expression; response to glucocorticoid stimulus; response to molecule of bacterial origin; T-helper 2 type immune response

Disease: Graft-versus-host Disease, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To; Rheumatoid Arthritis