Rabbit IL-3Rbeta Polyclonal Antibody | anti-IL-3Rbeta antibody

IL-3Rbeta (F587) Polyclonal Antibody

Cat. Num. AAA3000622

• Gene Names: CSF2RB; CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IL-3Rbeta; Polyclonal Antibody; IL-3Rbeta (F587) Polyclonal Antibody; Cytokine receptor common subunit beta; CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD131; CSF2RB; IL3RB; IL5RB; IL3Rbeta; anti-IL-3Rbeta antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IL-3R (F587) polyclonal antibody detects endogenous levels of IL-3R protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 897

• Applicable Applications for anti-IL-3Rbeta antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 550-600 of Human IL-3Rbeta.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of IL-3Rbeta (F587) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.)

Related Product Information for anti-IL-3Rbeta antibody

Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific alpha subunit (IL-3Ralpha) and a signal transducing beta subunit (IL-3Rbeta) common to the IL-3/IL-5/GM-CSF receptors. The alpha subunits are low-affinity ligand-binding proteins while the beta subunits do not themselves bind ligand, but are required for high affinity binding by the alpha subunits. The mouse IL-3 receptor has two distinct beta subunits, one that functions only in IL-3-mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine beta subunits are 91% homologous at the amino acid level but only 56% homologous to the human beta subunit.

NCBI and Uniprot Product Information

• NCBI GI #: 4559408
• NCBI GeneID: 1439
• NCBI Accession #: NP_000386.1
• NCBI GenBank Nucleotide #: NP_000386.1
• UniProt Accession #: P32927
• Molecular Weight: ~ 130kDa
• NCBI Official Full Name: cytokine receptor common subunit beta
• NCBI Official Synonym Full Names: colony stimulating factor 2 receptor subunit beta
• NCBI Official Symbol: CSF2RB
• NCBI Official Synonym Symbols: CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR
• NCBI Protein Information: cytokine receptor common subunit beta
• UniProt Protein Name: Cytokine receptor common subunit beta
• UniProt Gene Name: CSF2RB
• UniProt Synonym Gene Names: IL3RB; IL5RB
• UniProt Entry Name: IL3RB_HUMAN

NCBI Description

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

Uniprot Description

CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; interleukin-5 receptor activity; interleukin-3 receptor activity; receptor activity

Biological Process: response to lipopolysaccharide; respiratory gaseous exchange; signal transduction

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5