Immunohistochemistry
IL-18 Polyclonal Antibody | anti-IL-18 antibody
Rabbit anti IL-18 Polyclonal
Purity: >95%
Purity: >95%
Western blot: Use at a concentration range of 2-10 ug/ml.
Immunohistochemical (IHC): A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.
Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
Shelf Life: >12 months
Immunohistochemistry
Immunohistochemistry
• IL-18 and urinary ngal predict dialysis and graft recovery after kidney transplantation .J. Am. Soc. Nephrol., Sep 2009; 10.1681/ASN.2009030264.
• a functional polymorphism in IL-18 is associated with severity of bronchial asthma .Am. J. Respir. Crit. Care Med., Sep 2009; 10.1164/rccm.200905-0652 degree C.
• il-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection .J. Immunol., Sep 2009; 183: 3324 - 3331.
• neutrophil chemokines and their role in IL-18-mediated increase in neutrophil o2– production and intestinal edema following alcohol intoxication and burn injury .Am J Physiol Gastrointest Liver Physiol, Aug 2009; 297: G340 - G347.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Description
IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 11q22.2-q22.3
Cellular Component: extracellular space; extracellular region; cytosol
Molecular Function: protein binding; cytokine activity
Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; positive regulation of interleukin-17 production; regulation of cell adhesion; T-helper 1 type immune response; positive regulation of natural killer cell proliferation; T-helper 2 type immune response; interleukin-2 biosynthetic process; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response
Similar Products
Product Notes
The IL-18 il18 (Catalog #AAA551052) is an Antibody produced from Polyclonal anti IL-18 was produced from sera of rabbits immunized with synthetic protein containing IL-18 C Terminal antigenic determinants. and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti IL-18 Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IL-18 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA). ELISA: Use at a concentration range of 1-2ug/ml. Western blot: Use at a concentration range of 2-10 ug/ml. Immunohistochemical (IHC): A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml. Researchers should empirically determine the suitability of the IL-18 il18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
