Western Blot (WB)
(IHH Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IHH antibody detected the IHH protein (arrow).)
Rabbit IHH Polyclonal Antibody | anti-IHH antibody
IHH Antibody (N-term)
Western Blot (WB)
(IHH Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IHH antibody detected the IHH protein (arrow).)
Western Blot (WB)
(IHH Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the IHH antibody detected the IHH protein (arrow).)
Immunohistochemistry (IHC)
(IHH Antibody (N-term) (MBS9210052)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IHH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(IHH Antibody (N-term) (MBS9210052)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IHH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
secreted signaling molecules. Hedgehog proteins are essential
regulators of a variety of developmental processes including
growth, patterning and morphogenesis. The encoded protein
specifically plays a role in bone growth an differentiation.
Mutations in this gene are the cause of brachydactyly type A1 which
is characterized by shortening or malformation of the phalanges.
Mutations in this gene are also the cause of acrocapitofemoral
dysplasia.
Kang, S.J., et al. Hum. Mol. Genet. 19(13):2725-2738(2010)
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Chuang, P.T., et al. Nature 397(6720):617-621(1999)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]
Uniprot Description
IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.
Chromosomal Location of Human Ortholog: 2q33-q35
Cellular Component: extracellular matrix; extracellular space; plasma membrane
Molecular Function: peptidase activity; patched binding; calcium ion binding
Biological Process: vitelline membrane formation; proteoglycan metabolic process; maternal process involved in pregnancy; cell maturation; positive regulation of collagen biosynthetic process; cell fate specification; embryonic pattern specification; proteolysis; response to estradiol stimulus; positive regulation of T cell differentiation in the thymus; smooth muscle development; cell-cell signaling; embryonic digestive tract morphogenesis; regulation of growth; positive regulation of mesenchymal cell proliferation; pancreas development; positive regulation of smoothened signaling pathway; heart looping; skeletal development; bone resorption; negative regulation of immature T cell proliferation in the thymus; smoothened signaling pathway; intein-mediated protein splicing; in utero embryonic development; multicellular organism growth; negative regulation of eye pigmentation; negative regulation of T cell differentiation in the thymus; negative regulation of signal transduction; osteoblast differentiation; patterning of blood vessels; positive regulation of chondrocyte differentiation; cartilage development; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; positive regulation of epithelial cell proliferation; positive regulation of alpha-beta T cell differentiation; negative regulation of alpha-beta T cell differentiation; negative regulation of apoptosis
Disease: Brachydactyly, Type A1; Acrocapitofemoral Dysplasia
Research Articles on IHH
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Product Notes
The IHH ihh (Catalog #AAA9210052) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 51-80. The IHH Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's IHH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the IHH ihh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IHH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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