Goat IGFBP7 / TAF Polyclonal Antibody | anti-IGFBP7 antibody

Goat Polyclonal to Human IGFBP7 / TAF

Cat. Num. AAA247655

• Gene Names: IGFBP7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
• Reactivity: Gibbon, Bovine, Gorilla, Horse, Human, Monkey, Sheep; Predicted Reactivity: Dog, Pig, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: IGFBP7 / TAF; Polyclonal Antibody; Goat Polyclonal to Human IGFBP7 / TAF; Anti-IGFBP7 / TAF Antibody (Internal) IHC-plus; IGFBP7; AGM; FSTL2; IGFBP-7v; IGFBP-rP1; IBP-7; Angiomodulin; RAMSVPS; MAC25 protein; PSF; TAF; Tumor-derived adhesion factor; IGF-binding protein 7; IGFBP-7; IGFBPRP1; MAC25; PGI2-stimulating factor; Human IGFBP7; anti-IGFBP7 antibody

• Host: Goat
• Reactivity: Gibbon, Bovine, Gorilla, Horse, Human, Monkey, Sheep; Predicted Reactivity: Dog, Pig, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human IGFBP7.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 282

• Applicable Applications for anti-IGFBP7 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:16000), IHC-P (2.5 - 3.75 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-NKVKRGHYGVQRTE from an internal region of human IGFBP7 (NP_001544.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Sheep, Elephant, Bovine, Horse (100%); Dog, Rabbit, Pig, Opossum (93%).
• Immunogen Type: Synthetic peptide
• Immunogen: IGFBP7 / TAF antibody was raised against synthetic peptide C-NKVKRGHYGVQRTE from an internal region of human IGFBP7 (NP_001544.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Sheep, Elephant, Bovine, Horse (100%); Dog, Rabbit, Pig, Opossum (93%); Mouse, Rat (86%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-IGFBP7 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-IGFBP7 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4504619
• NCBI GeneID: 3490
• NCBI Accession #: NP_001544.1
• NCBI GenBank Nucleotide #: NM_001553.2
• UniProt Accession #: Q16270; Q07822; Q53YE6; Q9UCA8; B4E1N2; B7Z9W7
• Molecular Weight: 28,860 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 7 isoform 1
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 7
• NCBI Official Symbol: IGFBP7
• NCBI Official Synonym Symbols: AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
• NCBI Protein Information: insulin-like growth factor-binding protein 7; IGFBP-rP1; angiomodulin; IGF-binding protein 7; PGI2-stimulating factor; tumor-derived adhesion factor; prostacyclin-stimulating factor
• UniProt Protein Name: Insulin-like growth factor-binding protein 7
• Protein Family: Insulin-like growth factor-binding protein
• UniProt Gene Name: IGFBP7
• UniProt Synonym Gene Names: MAC25; PSF; IBP-7; IGF-binding protein 7; IGFBP-7; TAF
• UniProt Entry Name: IBP7_HUMAN

NCBI Description

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

Uniprot Description

IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

Protein type: Cell cycle regulation; Secreted, signal peptide; Cell adhesion; Secreted

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding; protein binding

Biological Process: negative regulation of cell proliferation; response to retinoic acid; response to cortisol stimulus; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus

Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis