Rabbit anti-Human IGF1 IGF1 Polyclonal Antibody | anti-IGF1 antibody

IGF1 antibody

Cat. Num. AAA535074

• Reactivity: Human IGF1
• Applications: ELISA, Western Blot
• Synonyms: IGF1; Polyclonal Antibody; IGF1 antibody; Polyclonal IGF1; Anti-IGF1; IGF-1; IGF-IA; Somatamedin C; IGF 1; Insulin-like Growth Factor-I; anti-IGF1 antibody

• Host: Rabbit
• Reactivity: Human IGF1
• Clonality: Polyclonal
• Specificity: Human IGF1
• Form/Format: Lyophilized from PBS, pH 7.2. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
• Sequence Length: 130

• Applicable Applications for anti-IGF1 antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Application Notes: ELISA: 0.5-2 ug/ml; Inhibition: 0.67-0.1 ug/ml; WB: 0.1-0.2 ug/ml
• Biological Significance: The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
• Immunogen: IGF1 antibody was raised in rabbit using highly pure recombinant human IGF-I as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-IGF1 antibody

Affinity purified Rabbit polyclonal IGF1 antibody

Product Categories/Family for anti-IGF1 antibody

Cytokines & Growth Factors; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 290543535
• NCBI GeneID: 100135551
• NCBI Accession #: NP_001166437.1
• NCBI GenBank Nucleotide #: NM_001172966.1
• UniProt Accession #: P17647
• Molecular Weight: 7.6 kDa (predicted detection band MW)
• NCBI Official Full Name: insulin-like growth factor I
• NCBI Official Symbol: Igf1
• NCBI Protein Information: insulin-like growth factor I
• UniProt Protein Name: Insulin-like growth factor I
• Protein Family: Insulin-like growth factor
• UniProt Gene Name: IGF1
• UniProt Synonym Gene Names: IGF-I
• UniProt Entry Name: IGF1_CAVPO

Uniprot Description

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 ().