Western Blot (WB)
(Western blot analysis of Ig lambda C expression in K562 (A), human spleen (B) whole cell lysates.)
Rabbit anti-Human Ig lambda C Polyclonal Antibody | anti-IGLC1 antibody
Anti-Ig lambda C Antibody
Western Blot (WB)
(Western blot analysis of Ig lambda C expression in K562 (A), human spleen (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Ig lambda C expression in K562 (A), human spleen (B) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: external side of plasma membrane; membrane
Molecular Function: antigen binding
Biological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; immune response; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activation
Disease: Agammaglobulinemia 2, Autosomal Recessive
Research Articles on IGLC1
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Product Notes
The IGLC1 igll1 (Catalog #AAA8241607) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Ig lambda C Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ig lambda C can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: (1/500 - 1/1000). Researchers should empirically determine the suitability of the IGLC1 igll1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ig lambda C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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