Rabbit anti-Human IFI6 Polyclonal Antibody | anti-IFI6 antibody

IFI6, NT (IFI6, G1P3, Interferon alpha-inducible protein 6, Interferon-induced protein 6-16) (Azide free) (HRP)

Cat. Num. AAA6309259

• Gene Names: IFI6; 6-16; G1P3; FAM14C; IFI616; IFI-6-16
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IFI6; Polyclonal Antibody; NT (IFI6; G1P3; Interferon alpha-inducible protein 6; Interferon-induced protein 6-16) (Azide free) (HRP); Interferon-induced protein 6-16; anti-IFI6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-IFI6 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: IFI6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of human IFI6.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(IFI6 Antibody (N-term) western blot analysis in MDA-MB453,CEM cell line lysates (35ug/lane).This demonstrates the IFI6 antibody detected the IFI6 protein (arrow).)

Related Product Information for anti-IFI6 antibody

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.

Product Categories/Family for anti-IFI6 antibody

Antibodies; Interferon

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010). Szegedi, K., et al. Exp. Dermatol. 19(3):269-278(2010). Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010): Zhao, D., et al. Virol. J. 5, 114 (2008): Cheriyath, V., et al. J. Clin. Invest. 117(10):3107-3117(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 13259552
• NCBI GeneID: 2537
• NCBI Accession #: NP_002029.3
• NCBI GenBank Nucleotide #: NM_002038.3
• UniProt Accession #: P09912; Q13141; Q13142; Q5VVR2; Q5VVR3; Q6IE95; Q969M8
• Molecular Weight: 12,927 Da
• NCBI Official Full Name: interferon alpha-inducible protein 6 isoform a
• NCBI Official Synonym Full Names: interferon, alpha-inducible protein 6
• NCBI Official Symbol: IFI6
• NCBI Official Synonym Symbols: 6-16; G1P3; FAM14C; IFI616; IFI-6-16
• NCBI Protein Information: interferon alpha-inducible protein 6; interferon-induced protein 6-16; interferon, alpha-inducible protein clone IFI-6-16
• UniProt Protein Name: Interferon alpha-inducible protein 6
• Protein Family: Interferon alpha-inducible protein
• UniProt Gene Name: IFI6
• UniProt Synonym Gene Names: G1P3; Ifi-6-16
• UniProt Entry Name: IFI6_HUMAN

NCBI Description

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

IFI6: first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35

Cellular Component: mitochondrion; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: release of cytochrome c from mitochondria; cytokine and chemokine mediated signaling pathway; immune response; negative regulation of caspase activity; negative regulation of mitochondrial depolarization