Western Blot (WB)
(Host: RabbitTarget Name: IFI204Sample Tissue: Mouse NIH3T3 Whole CellAntibody Dilution: 1ug/ml)
Rabbit anti-Mouse Ifi204 Polyclonal Antibody | anti-IFI204 antibody
Ifi204 antibody - middle region
Western Blot (WB)
(Host: RabbitTarget Name: IFI204Sample Tissue: Mouse NIH3T3 Whole CellAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IFI204Sample Tissue: Mouse NIH3T3 Whole CellAntibody Dilution: 1ug/ml)
Western Blot (WB)
(WB Suggested Anti-Ifi204 Antibody Titration: 0.2-1 ug/mlPositive Control: Mouse Lung)
Western Blot (WB)
(WB Suggested Anti-Ifi204 Antibody Titration: 0.2-1 ug/mlPositive Control: Mouse Lung)
Target Description: Ifi204 inhibits the transcription of ribosomal RNA.Ifi204 may inhibit DNA binding by UBTF. Ifi204 inhibits cell growth via TP53/p53 and RB1-dependent and independent pathways.Ifi204 acts as a coactivator of RUNX2 during osteogenesis. Ifi204 may be involved in macrophage differentiation.Ifi204 enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.
NCBI and Uniprot Product Information
Uniprot Description
IFI16: a nuclear protein that may function as a transcriptional repressor. Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. Binds double-stranded DNA and cell cycle regulatory factors including p53 and Rb. Loss of IFI16 activates p53 checkpoint through NBS1-DNAPK pathway. Inhibits cell growth in the Ras/Raf signaling pathway. May be involved in the senescence of prostate epithelial cells. Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast. Four alternatively spliced isoforms have been described. Isoforms-1, -2 and -3 can homo- and hetero-dimerize.
Protein type: Transcription factor
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nuclear speck; nucleus
Molecular Function: identical protein binding; protein binding; double-stranded DNA binding; transcription cofactor activity; transcription factor binding
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; positive regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; inner ear development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Research Articles on IFI204
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Product Notes
The IFI204 ifi204 (Catalog #AAA3203358) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ifi204 antibody - middle region reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ifi204 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the IFI204 ifi204 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: EAGPATPTST TSHMLASERG ETSATQEETS TAQAGTSTAQ ARTSTAQAGT. It is sometimes possible for the material contained within the vial of "Ifi204, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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