Rabbit anti-Mouse, Rat ICAM1 Polyclonal Antibody | anti-ICAM1 antibody

Anti-ICAM1 antibody

Cat. Num. AAA177098

• Gene Names: Icam1; CD54; Ly-47; Icam-1; MALA-2
• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: ICAM1; Polyclonal Antibody; Anti-ICAM1 antibody; Intercellular adhesion molecule 1; intercellular adhesion molecule 1; Antigen identified by monoclonal antibody BB2 antibody; BB 2 antibody; BB2 antibody; CD 54 antibody; CD_antigen; CD54 antibody; CD54 antigen antibody; Cell surface glycoprotein P3.58 antibody; Human rhinovirus receptor antibody; ICAM 1 antibody; ICAM-1 antibody; ICAM1 antibody; ICAM1_HUMAN antibody; intercellular adhesion molecule 1(CD54); human rhinovirus receptor antibody; Intercellular adhesion molecule 1 antibody; Major group rhinovirus receptor antibody; MALA 2 antibody; MALA2 antibody; MyD 10 antibody; MyD10 antibody; P3.58 antibody; Surface antigen of activated B cells antibody; Surface antigen of activated B cells; anti-ICAM1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 537

• Applicable Applications for anti-ICAM1 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Immunogen: E Coli-derived mouse ICAM1 recombinant protein (Position: G198-P537). Mouse ICAM1 shares 74% amino acid (aa) sequence identity with rat ICAM1.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-ICAM1 Picoband antibody, MBS177098-1.JPGIHC(P): Mouse Intestine Tissue )

Immunohistochemistry (IHC)

(Anti-ICAM1 Picoband antibody, MBS177098-2.JPGIHC(P): Mouse Lung Tissue )

Immunohistochemistry (IHC)

(Anti-ICAM1 Picoband antibody, MBS177098-3.JPGIHC(P): Mouse Spleen Tissue )

Immunohistochemistry (IHC)

(Anti-ICAM1 Picoband antibody, MBS177098-4.JPGIHC(P): Rat Intestine Tissue )

Immunohistochemistry (IHC)

(Anti-ICAM1 Picoband antibody, MBS177098-5.JPGIHC(P): Rat Spleen Tissue )

Testing Data

(Anti-ICAM1 Picoband antibody, MBS177098-6.jpgAll lanes: Anti-ICAM1(MBS177098) at 0.5ug/mlLane 1: Rat Thymus Tissue Lysate at 40ugLane 2: Rat Spleen Tissue Lysate at 40ugLane 3: PC12 Whole Cell Lysate at 40ugLane 4: NRK Whole Cell Lysate at 40ugLane 5: RH35 Whole Cell Lysate at 40ugPredicted bind size: 58KDObserved bind size: 90KD )

Related Product Information for anti-ICAM1 antibody

Description: Rabbit IgG polyclonal antibody for Intercellular adhesion molecule 1(ICAM1) detection. Tested with WB, IHC-P in Mouse, Rat.
Background: Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for lymphocyte function-associated (LFA) antigens, a beta 2 leukocyte integrin. The normal function of human ICAM-1 is to provide adhesion between endothelial cells and leukocytes after injury or stress. ICAM-1 binds to leukocyte function-associated antigen (LFA-1) or macrophage-1 antigen (Mac-1). It is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses.

NCBI and Uniprot Product Information

• NCBI GI #: 124099
• NCBI GeneID: 15894
• UniProt Accession #: P13597; Q61828
• Molecular Weight: 58,753 Da
• NCBI Official Full Name: Intercellular adhesion molecule 1
• NCBI Official Synonym Full Names: intercellular adhesion molecule 1
• NCBI Official Symbol: Icam1
• NCBI Official Synonym Symbols: CD54; Ly-47; Icam-1; MALA-2
• NCBI Protein Information: intercellular adhesion molecule 1; myD10
• UniProt Protein Name: Intercellular adhesion molecule 1
• Protein Family: Intercellular adhesion molecule
• UniProt Gene Name: Icam1
• UniProt Synonym Gene Names: Icam-1; ICAM-1
• UniProt Entry Name: ICAM1_MOUSE

Uniprot Description

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Membrane protein, integral; Cell adhesion; Immunoglobulin superfamily

Cellular Component: extracellular space; focal adhesion; cell surface; membrane; integral to plasma membrane; integral to membrane; plasma membrane; immunological synapse; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein complex binding

Biological Process: regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell adhesion; leukocyte adhesion; sensory perception of sound; positive regulation of actin filament polymerization; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; positive regulation of vasoconstriction; cell adhesion mediated by integrin; adhesion to host; cell adhesion; acute inflammatory response to antigenic stimulus