Rabbit anti-Human I23O2 Polyclonal Antibody | anti-I23O2 antibody

I23O2, CT (IDO2, INDOL1, Indoleamine 2,3-dioxygenase 2, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1) (MaxLight 650)

Cat. Num. AAA6309010

• Gene Names: IDO2; INDOL1
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: I23O2; Polyclonal Antibody; CT (IDO2; INDOL1; Indoleamine 2; 3-dioxygenase 2; 3-dioxygenase-like protein 1; Indoleamine-pyrrole 2; 3-dioxygenase-like protein 1) (MaxLight 650); IDO2; anti-I23O2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-I23O2 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: I23O2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the C-terminal region of human I23O2.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-I23O2 antibody

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).

Product Categories/Family for anti-I23O2 antibody

Antibodies; Enzymes; Oxidase

References

Cetindere, T., et al. Cell. Signal. 22(2):197-211(2010). Huttunen, R., et al. Shock 33(2):149-154(2010). Witkiewicz, A.K., et al. J. Am. Coll. Surg. 208(5):781-787(2009). Metz, R., et al. Cancer Res. 67(15):7082-7087(2007). Ball, H.J., et al. Gene 396(1):203-213(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 148539554
• NCBI GeneID: 169355
• NCBI Accession #: NP_919270.2
• NCBI GenBank Nucleotide #: NM_194294.2
• UniProt Accession #: Q6ZQW0; A4UD41; F5H5G0
• Molecular Weight: 19,610 Da
• NCBI Official Full Name: indoleamine 2,3-dioxygenase 2
• NCBI Official Synonym Full Names: indoleamine 2,3-dioxygenase 2
• NCBI Official Symbol: IDO2
• NCBI Official Synonym Symbols: INDOL1
• NCBI Protein Information: indoleamine 2,3-dioxygenase 2
• UniProt Protein Name: Indoleamine 2,3-dioxygenase 2
• UniProt Gene Name: IDO2
• UniProt Synonym Gene Names: INDOL1; IDO-2
• UniProt Entry Name: I23O2_HUMAN

NCBI Description

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

Uniprot Description

INDOL1: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Belongs to the indoleamine 2,3-dioxygenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.-

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: cytoplasm; cytosol

Molecular Function: metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity

Biological Process: tryptophan catabolic process to kynurenine; tryptophan catabolic process