Rabbit anti-Human HTR7 Polyclonal Antibody | anti-HTR7 antibody

HTR7, CT (HTR7, 5-hydroxytryptamine receptor 7, 5-HT-X, Serotonin receptor 7) (FITC)

Cat. Num. AAA6308873

• Gene Names: HTR7; 5-HT7
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HTR7; Polyclonal Antibody; CT (HTR7; 5-hydroxytryptamine receptor 7; 5-HT-X; Serotonin receptor 7) (FITC); Serotonin receptor 7; anti-HTR7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-HTR7 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HTR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-433 amino acids from the C-terminal region of human HTR7.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HTR7 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the HTR7 antibody detected the HTR7 protein (arrow).)

Related Product Information for anti-HTR7 antibody

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.

Product Categories/Family for anti-HTR7 antibody

Antibodies; Receptors

References

Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010): Corominas, R., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1), 177-184 (2010): Wei, Z., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 33(3):547-551(2009). Iceta, R., et al. J. Physiol. Pharmacol. 60(1):157-164(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 10880129
• NCBI GeneID: 3363
• NCBI Accession #: NP_062873.1; NP_000863.1
• NCBI GenBank Nucleotide #: NM_019859.3
• UniProt Accession #: P34969; P78336; P78372; P78516; Q5VX01; Q5VX02; Q5VX03; B5BUP6
• Molecular Weight: 47,984 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 7 isoform d
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
• NCBI Official Symbol: HTR7
• NCBI Official Synonym Symbols: 5-HT7
• NCBI Protein Information: 5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
• UniProt Protein Name: 5-hydroxytryptamine receptor 7
• Protein Family: Transducer protein
• UniProt Gene Name: HTR7
• UniProt Synonym Gene Names: 5-HT-7; 5-HT7
• UniProt Entry Name: 5HT7R_HUMAN

NCBI Description

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

Uniprot Description

5-HT(7): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q21-q24

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: serotonin receptor activity

Biological Process: circadian rhythm; vasoconstriction; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; smooth muscle contraction; blood circulation; serotonin receptor signaling pathway