Rabbit HSPH1 / HSP110 Polyclonal Antibody | anti-HSPH1 antibody

Rabbit Polyclonal to Hamster HSPH1 / HSP110

Cat. Num. AAA246737

• Gene Names: HSPH1; HSP105; HSP105A; HSP105B; NY-CO-25
• Reactivity: Bovine, Hamster, Human, Monkey, Mouse, Rat, Sheep, Yeast
• Applications: Immunohistochemistry, Western Blot
• Purity: Affinity Purified
• Synonyms: HSPH1 / HSP110; Polyclonal Antibody; Rabbit Polyclonal to Hamster HSPH1 / HSP110; Anti-HSPH1 / HSP110 Antibody IHC-plus; HSPH1; Heat shock 105kD beta; Heat shock 110 kDa protein; Heat shock protein 105 kDa; HSP105; HSP110; Heat-shock protein 105 kd; HSP105A; HSP105B; NY-CO-25; KIAA0201; Antigen NY-CO-25; Heat shock 105kD alpha; Heat shock 105kDa protein 1; Hamster HSPH1; anti-HSPH1 antibody

• Host: Rabbit
• Reactivity: Bovine, Hamster, Human, Monkey, Mouse, Rat, Sheep, Yeast
• Clonality: Polyclonal
• Specificity: Detects ~110 kD protein.
• Purity/Purification: Affinity Purified
• Form/Format: PBS, pH 7.2, 50% glycerol, 0.09% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 858

• Applicable Applications for anti-HSPH1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (1:1000)
• Target Species: Hamster
• Immunogen Description: Synthetic peptide derived from the sequence of hamster Hsp110; sequence identical to human and mouse.
• Immunogen Type: Synthetic peptide
• Immunogen: HSPH1 / HSP110 antibody was raised against synthetic peptide derived from the sequence of hamster Hsp110; sequence identical to human and mouse.
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-HSP110 / Heat Shock Protein 110 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot analysis of Hsp110 in a human cell mix using a 1:1000 dilution of HSPH1 / HSP110 antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 42544159
• NCBI GeneID: 10808
• NCBI Accession #: NP_006635.2
• NCBI GenBank Nucleotide #: NM_006644.3
• UniProt Accession #: Q92598; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1
• Molecular Weight: 97,460 Da
• NCBI Official Full Name: heat shock protein 105 kDa isoform 1
• NCBI Official Synonym Full Names: heat shock 105kDa/110kDa protein 1
• NCBI Official Symbol: HSPH1
• NCBI Official Synonym Symbols: HSP105; HSP105A; HSP105B; NY-CO-25
• NCBI Protein Information: heat shock protein 105 kDa; antigen NY-CO-25; heat shock 105kD beta; heat shock 105kD alpha
• UniProt Protein Name: Heat shock protein 105 kDa
• Protein Family: Heat shock protein
• UniProt Gene Name: HSPH1
• UniProt Synonym Gene Names: HSP105; HSP110; KIAA0201
• UniProt Entry Name: HS105_HUMAN

Uniprot Description

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol

Molecular Function: protein binding; alpha-tubulin binding; ATP binding

Biological Process: receptor-mediated endocytosis; positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; response to unfolded protein