Western Blot (WB)
(Western Blot analysis of VEC cells with Phospho-HSP90beta (Ser226) Polyclonal Antibody )
Rabbit HSP90beta Polyclonal Antibody | anti-HSP90beta antibody
Phospho-HSP90beta (Ser226) Polyclonal Antibody
IHC: 1:100-1:300
IF: 1:200-1:1000
ELISA: 1:10000
Western Blot (WB)
(Western Blot analysis of VEC cells with Phospho-HSP90beta (Ser226) Polyclonal Antibody )
Western Blot (WB)
(Western Blot analysis of VEC cells with Phospho-HSP90beta (Ser226) Polyclonal Antibody )
NCBI and Uniprot Product Information
Observed Molecular Weight: 83kDa
NCBI Description
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
Uniprot Description
HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: apical plasma membrane; aryl hydrocarbon receptor complex; basolateral plasma membrane; brush border membrane; cell surface; cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; inclusion body; lysosomal membrane; melanosome; membrane; mitochondrion; nucleoplasm; nucleus; ooplasm; protein complex; secretory granule lumen; signalosome; sperm head plasma membrane
Molecular Function: ATP binding; ATP-dependent protein binding; cadherin binding; dATP binding; double-stranded RNA binding; drug binding; GTP binding; heat shock protein binding; histone deacetylase binding; histone methyltransferase binding; identical protein binding; ion channel binding; kinase binding; nitric-oxide synthase regulator activity; peptide binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein kinase regulator activity; RNA binding; sulfonylurea receptor binding; TPR domain binding; unfolded protein binding
Biological Process: cellular response to interleukin-4; cellular response to organic cyclic compound; chaperone-mediated protein complex assembly; Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of cell cycle arrest; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of transforming growth factor beta activation; neutrophil degranulation; placenta development; positive regulation of cell differentiation; positive regulation of cell size; positive regulation of nitric oxide biosynthetic process; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of protein localization to cell surface; positive regulation of protein serine/threonine kinase activity; positive regulation of telomerase activity; positive regulation of transforming growth factor beta receptor signaling pathway; protein folding; protein stabilization; regulation of cellular response to heat; regulation of protein ubiquitination; response to cocaine; response to salt stress; response to unfolded protein; telomerase holoenzyme complex assembly; telomere maintenance via telomerase; virion attachment to host cell surface receptor; xenobiotic metabolic process
Research Articles on HSP90beta
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Product Notes
The HSP90beta hsp90ab1 (Catalog #AAA2548832) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-HSP90beta (Ser226) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HSP90beta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA). WB: 1:500-1:2000 IHC: 1:100-1:300 IF: 1:200-1:1000 ELISA: 1:10000. Researchers should empirically determine the suitability of the HSP90beta hsp90ab1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSP90beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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