Rabbit anti-Mouse Hsp90 alpha Polyclonal Antibody | anti-HSP90AA1 antibody

Anti-Hsp90 alpha Antibody, Rabbit Polyclonal

Cat. Num. AAA8103366

• Gene Names: Hsp90aa1; hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1; AL024080; AL024147
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: Hsp90 alpha; Polyclonal Antibody; Anti-Hsp90 alpha Antibody; Rabbit Polyclonal; Hsp90 alpha Antibody; Rabbit PAb; Antigen Affinity Purified; heat shock protein 90kDa alpha (cytosolic); class A member 1; Anti-86kDa Antibody; Anti-89kDa Antibody; Anti-AL024080 Antibody; Anti-AL024147 Antibody; Anti-hsp4 Antibody; Anti-Hsp86-1 Antibody; Anti-Hsp89 Antibody; Anti-Hsp90 Antibody; Anti-Hspca Antibody; anti-HSP90AA1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse Hsp90 alpha
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-HSP90AA1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the center region of the Mouse Hsp90 alpha
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse Hsp90 alpha, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse HSP90AA1 in mouse kidney with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-HSP90AA1 antibody

Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoeostatic control mechanisms. HSP90 interacts with 'client proteins', including protein kinases, transcription factors, and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By this means, HSP90 displays a multifaceted ability to influence signal transduction, chromatin remodeling and epigenetic regulation, development, and morphological evolution. HSP90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis at the N-terminus. Disruption of HSP90 leads to client protein degradation and often cell death. Under stressful conditions, HSP90 stabilizes its client proteins and protects the cell against cellular stressors such as in cancer cells. Especially, several oncoproteins act as HSP90 client proteins and tumor cells require higher HSP90 activity than normal cells to maintain their malignancy. For this reason, Hsp90 has emerged as a promising target for anti-cancer drug development.

Product Categories/Family for anti-HSP90AA1 antibody

Cancer Drug Targets; Actin Dynamics Signaling Pathway

References

Pearl LH, et al. (2008) The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J. 410(3): 439-53.Hahn JS. (2009) The Hsp90 chaperone machinery: from structure to drug development. BMB Rep. 42(10): 623-30.Holzbeierlein JM, et al. (2010) Hsp90: a drug target? Curr Oncol Rep. 12(2): 95-101.Trepel J, et al. (2010) Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer. 10(8): 537-49.

NCBI and Uniprot Product Information

• NCBI GI #: 6754254
• NCBI GeneID: 15519
• NCBI Accession #: NP_034610.1
• NCBI GenBank Nucleotide #: NM_010480.5
• UniProt Accession #: P07901
• Molecular Weight: 84,788 Da
• NCBI Official Full Name: heat shock protein HSP 90-alpha
• NCBI Official Synonym Full Names: heat shock protein 90, alpha (cytosolic), class A member 1
• NCBI Official Symbol: Hsp90aa1
• NCBI Official Synonym Symbols: hsp4; 86kDa; 89kDa; Hsp89; Hsp90; Hspca; Hsp86-1; AL024080; AL024147
• NCBI Protein Information: heat shock protein HSP 90-alpha; TSTA; HSP86; HSP 86; heat shock 86 kDa; heat shock protein, 1; heat shock protein, 89 kDa; heat shock protein 1, alpha; heat shock protein, 86 kDa 1; tumor-specific transplantation 86 kDa antigen; heat shock protein 90kDa
• UniProt Protein Name: Heat shock protein HSP 90-alpha
• Protein Family: Heat shock protein
• UniProt Gene Name: Hsp90aa1
• UniProt Synonym Gene Names: Hsp86; Hsp86-1; Hspca; HSP 86; HSP86; TSTA
• UniProt Entry Name: HS90A_MOUSE