Rabbit HSP40 Polyclonal Antibody | anti-HSP40 antibody

HSP40 Rabbit pAb

Cat. Num. AAA8808441

• Gene Names: DNAJB1; Hdj1; Sis1; HSPF1; Hsp40; RSPH16B
• Reactivity: Human, Mouse, Rat
• Synonyms: HSP40; Polyclonal Antibody; HSP40 Rabbit pAb; DNA J B1; HDJ1; HSPF1; anti-HSP40 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: PBS with 0.02% sodium azide and 50% glycerol pH7.4.
• Concentration: 1mg/ml (varies by lot)

• Species: Human
• Immunogen: Recombinant Protein
• Preparation and Storage: Store at -20 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using HSP40 (EA337) Rabbit pAb diluted at 1:200.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using HSP40(EA337)Rabbit pAb diluted at 1:200)

Western Blot (WB)

(Western blot analysis of 1) C2C12 Cell Lysate, 2)PC12 Cell Lysate, 3) Hela Cell Lysate using HSP40 (EA337)Rabbit pAb diluted at 1:1000.)

Related Product Information for anti-HSP40 antibody

HSP40 and HSP40-like proteins represent a large family of chaperone proteins that are homologous to E. coli DnaJ protein. HSP40 family proteins bind unfolded proteins, prevent their aggregation, and then deliver them to HSP70. Another major function of HSP40 is to stimulate ATPase activity of HSP70, which causes conformational change of the unfolded proteins.

NCBI and Uniprot Product Information

• NCBI GI #: 5453690
• NCBI GeneID: 3337
• NCBI Accession #: NP_006136.1
• NCBI GenBank Nucleotide #: NM_006145.1
• UniProt Accession #: P25685
• Molecular Weight: 38,044 Da
• NCBI Official Full Name: dnaJ homolog subfamily B member 1
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily B, member 1
• NCBI Official Symbol: DNAJB1
• NCBI Official Synonym Symbols: Hdj1; Sis1; HSPF1; Hsp40; RSPH16B
• NCBI Protein Information: dnaJ homolog subfamily B member 1; hDj-1; human DnaJ protein 1; heat shock protein 40; dnaJ protein homolog 1; heat shock 40kD protein 1; radial spoke 16 homolog B; heat shock 40 kDa protein 1; DnaJ (Hsp40) homolog, subfmaily B, member 1
• UniProt Protein Name: DnaJ homolog subfamily B member 1
• UniProt Gene Name: DNAJB1
• UniProt Synonym Gene Names: DNAJ1; HDJ1; HSPF1; HSP40; Heat shock protein 40; hDj-1
• UniProt Entry Name: DNJB1_HUMAN

Uniprot Description

Function: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.

Subunit structure: Interacts with DNAJC3. Interacts with SRPK1. Ref.6 Ref.7

Subcellular location: Cytoplasm. Nucleus. Nucleus › nucleolus. Note: Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock. Ref.5

Induction: By heat shock. Ref.5

Sequence similarities: Contains 1 J domain.

Sequence caution: The sequence CAA44287.1 differs from that shown. Reason: Frameshift at positions 11, 28, 81 and 136.