Rabbit Hsc70 Polyclonal Antibody | anti-Hsc70 antibody

Hsc70 Rabbit Polyclonal

Cat. Num. AAA7600252

• Gene Names: HSPA8; Hsc70; HSPA10
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: Hsc70; Polyclonal Antibody; Hsc70 Rabbit Polyclonal; anti-Hsc70 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 650

• Applicable Applications for anti-Hsc70 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
• Immunogen: Heat shock 70kDa protein 8
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tumor using MBS7600252 (HSPA8 antibody) at dilution of 1:100)

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7600252 (Hsc70 Antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 76253709
• NCBI GeneID: 281831
• NCBI Accession #: NP_776770.2
• NCBI GenBank Nucleotide #: NM_174345.4
• Molecular Weight: 71,241 Da
• NCBI Official Full Name: heat shock cognate 71 kDa protein
• NCBI Official Symbol: HSPA8
• NCBI Official Synonym Symbols: Hsc70; HSPA10
• NCBI Protein Information: heat shock cognate 71 kDa protein
• UniProt Protein Name: Heat shock cognate 71 kDa protein
• Protein Family: Hsc70-interacting protein
• UniProt Gene Name: HSPA8
• UniProt Synonym Gene Names: HSC70
• UniProt Entry Name: HSP7C_BOVIN

Uniprot Description

GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Heat shock protein; Chaperone

Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; focal adhesion; integral to endoplasmic reticulum membrane; melanosome; membrane; midbody; mitochondrion; myelin sheath; nucleus; plasma membrane; signalosome; smooth endoplasmic reticulum

Molecular Function: ATP binding; ATPase activity; enzyme binding; glycoprotein binding; misfolded protein binding; protein binding; protein domain specific binding; ribosome binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: cellular response to glucose starvation; cerebellar Purkinje cell layer development; cerebellum structural organization; ER overload response; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; positive regulation of protein ubiquitination; proteolysis involved in cellular protein catabolic process; substantia nigra development; unfolded protein response, activation of signaling protein activity