Rabbit anti-Human HS3ST3A1 Polyclonal Antibody | anti-HS3ST3A1 antibody

HS3ST3A1 (3OST3A1, HS3ST3A, Heparan Sulfate Glucosamine 3-O-sulfotransferase 3A1, Heparan Sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, 3-OST-3A, h3-OST-3A, UNQ2551/PRO6180) (FITC)

Cat. Num. AAA6381675

• Gene Names: HS3ST3A1; 30ST3A1; 3OST3A1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HS3ST3A1; Polyclonal Antibody; HS3ST3A1 (3OST3A1; HS3ST3A; Heparan Sulfate Glucosamine 3-O-sulfotransferase 3A1; Heparan Sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; 3-OST-3A; h3-OST-3A; UNQ2551/PRO6180) (FITC); anti-HS3ST3A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human HS3ST3A1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-HS3ST3A1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human HS3ST3A1, aa1-406 (NP_006033.1).
• Immunogen Sequence: MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of HS3ST3A1 expression in transfected 293T cell line by HS3ST3A1 polyclonal antibody. Lane 1: HS3ST3A1 transfected lysate (44.9kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-HS3ST3A1 antibody

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Product Categories/Family for anti-HS3ST3A1 antibody

Antibodies; Enzymes; Sulfotransferase

NCBI and Uniprot Product Information

• NCBI GI #: 5174465
• NCBI GeneID: 9955
• NCBI Accession #: NP_006033.1
• NCBI GenBank Nucleotide #: NM_006042.1
• UniProt Accession #: Q9Y663; A8K7N2
• Molecular Weight: 44,900 Da
• NCBI Official Full Name: heparan sulfate glucosamine 3-O-sulfotransferase 3A1
• NCBI Official Synonym Full Names: heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
• NCBI Official Symbol: HS3ST3A1
• NCBI Official Synonym Symbols: 30ST3A1; 3OST3A1
• NCBI Protein Information: heparan sulfate glucosamine 3-O-sulfotransferase 3A1; 3-OST-3A; h3-OST-3A; heparan sulfate 3-O-sulfotransferase 3A1; heparin-glucosamine 3-O-sulfotransferase; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
• UniProt Protein Name: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
• Protein Family: Heparan sulfate glucosamine 3-O-sulfotransferase
• UniProt Gene Name: HS3ST3A1
• UniProt Synonym Gene Names: 3OST3A1; HS3ST3A; 3-OST-3A; Heparan sulfate 3-O-sulfotransferase 3A1; h3-OST-3A
• UniProt Entry Name: HS3SA_HUMAN

NCBI Description

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Jul 2008]

Uniprot Description

HS3ST3A1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. Belongs to the sulfotransferase 1 family.

Protein type: Membrane protein, integral; Glycan Metabolism - glycosaminoglycan degradation; Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.8.2.23

Chromosomal Location of Human Ortholog: 17p12

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: sulfotransferase activity; [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

Biological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis