Western Blot (WB)
(HRC Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the HRC antibody detected the HRC protein (arrow).)
Rabbit anti-Human HRC Polyclonal Antibody | anti-HRC antibody
HRC Antibody (Center)
Western Blot (WB)
(HRC Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the HRC antibody detected the HRC protein (arrow).)
Western Blot (WB)
(HRC Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the HRC antibody detected the HRC protein (arrow).)
Immunohistochemistry (IHC)
(HRC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HRC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(HRC Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HRC Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
identified by its ability to bind low-density lipoprotein with high
affinity. The protein interacts with the cytoplasmic domain of
triadin, the main transmembrane protein of the junctional
sarcoplasmic reticulum (SR) of skeletal muscle. The protein
functions in the regulation of releasable calcium into the SR.
Arvanitis, D.A., et al. Am. J. Physiol. Heart Circ. Physiol. 293 (3), H1581-H1589 (2007) :
Fan, G.C., et al. Am. J. Physiol. Heart Circ. Physiol. 287 (4), H1705-H1711 (2004) :
Anderson, J.P., et al. Mol. Cell. Biol. 24(9):3757-3768(2004)
Adkins, J.N., et al. Mol. Cell Proteomics 1(12):947-955(2002)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]
Uniprot Description
HRC: May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; Z disc
Molecular Function: protein binding; calcium ion binding; ATPase binding
Biological Process: cytosolic calcium ion homeostasis; muscle contraction; regulation of heart rate; regulation of peptidyl-serine phosphorylation; positive regulation of heart rate; positive regulation of heart contraction
Research Articles on HRC
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Product Notes
The HRC hrc (Catalog #AAA9212117) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 277-306. The HRC Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HRC can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the HRC hrc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HRC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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