Goat HPV11 E6 Polyclonal Antibody | anti-HPV11 E6 antibody

HPV11 E6 Polyclonal Antibody

Cat. Num. AAA448009

• Reactivity: Human papilloma viruses type 11
• Applications: Western Blot
• Synonyms: HPV11 E6; Polyclonal Antibody; HPV11 E6 Polyclonal Antibody; Anti-HPV11 E6; anti-HPV11 E6 antibody

• Host: Goat
• Reactivity: Human papilloma viruses type 11
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Detects HPV11 E6 recombinant fusion proteins MBP-E6 and GFP-E6 expressed in transfected mammalian cells.
• Form/Format: Polyclonal antibody supplied as (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.

• Applicable Applications for anti-HPV11 E6 antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:500-1:2,000
• Immunogen: Purified recombinant peptide derived from within residues 65 aa to N-terminal of HPV11 E6 produced in E. coli.
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: Store at -20 degree C for long term storage. Store at 2-8 degree C for up to one month. Avoid freeze/thaw cycles.

Reactivity Chart

Testing Data

Related Product Information for anti-HPV11 E6 antibody

Goat polyclonal antibody to HPV11 E6. E6 is one primary oncoprotein of high risk HPV types expressed early in the HPV life cycle. After the host cell is infected viral early promoter is activated and a polycistronic primary RNA containing all six early ORFs is transcribed. This polycistronic RNA then undergoes active RNA splicing to generate multiple isoforms of mRNAs. One of the spliced isoform RNAs, E6, serves as an E7 mRNA to translate E7 protein. HPV genome integrate into host genome by disruption of E2 ORF, preventing E2 repression on E6 and E7. Thus, viral genome integration into host DNA genome increases E6 expression. The E6 protein inactivates the tumour suppressor protein, p53 and promote cellular proliferation and the chance of malignancy.