Rabbit anti-Human, Mouse HOXA11 Polyclonal Antibody | anti-HOXA11 antibody

HOXA11 Antibody

Cat. Num. AAA9410862

• Gene Names: HOXA11; HOX1; HOX1I
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Synonyms: HOXA11; Polyclonal Antibody; HOXA11 Antibody; homeobox A11; HOX1; HOX1I; anti-HOXA11 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total HOXA11 protein.
• Form/Format: Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
• Sequence Length: 313

• Applicable Applications for anti-HOXA11 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA: 1:1000-1:2000; Western blotting: 1:500-1:2000; Immunohistochemistry: 1:10-1:50
• Immunogen Type: Peptide-KLH
• Immunogen Description: Synthetic peptide corresponding to a region derived from 144-159 amino acids of Human homeobox A11
• Target Name: HOXA11
• Preparation and Storage: Store at -20 degree C/1 year

Testing Data

(Gel: 10%SDS-PAGE Lysate: 40 ug Hela cell lysate Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes)

Immunohistochemistry (IHC)

(The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 31221 (HOXA11 Antibody) at dilution 1/10, on the right is treated with the synthetic peptide.)

Related Product Information for anti-HOXA11 antibody

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.

Product Categories/Family for anti-HOXA11 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5031759
• NCBI GeneID: 3207
• NCBI Accession #: NP_005514
• NCBI GenBank Nucleotide #: NM_005523.5
• Molecular Weight: 34,486 Da
• NCBI Official Full Name: homeobox protein Hox-A11
• NCBI Official Synonym Full Names: homeobox A11
• NCBI Official Symbol: HOXA11
• NCBI Official Synonym Symbols: HOX1; HOX1I
• NCBI Protein Information: homeobox protein Hox-A11
• UniProt Protein Name: Homeobox protein Hox-A11
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXA11
• UniProt Synonym Gene Names: HOX1I
• UniProt Entry Name: HXA11_HUMAN

NCBI Description

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

Uniprot Description

HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: transcription factor complex; protein complex; nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; developmental growth; anatomical structure morphogenesis; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; male gonad development; uterus development; anterior/posterior pattern formation; positive regulation of chondrocyte differentiation; dorsal/ventral pattern formation; ureteric bud branching; induction of an organ; single fertilization; mesodermal cell fate specification; spermatogenesis; embryonic digit morphogenesis; metanephros development; skeletal development; proximal/distal pattern formation; embryonic limb morphogenesis

Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia