Western Blot (WB)
(Western blot analysis of lysate from mouse lung tissue lysate, using Mouse Hoxa1 Antibody (Center). MBS9210264 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Rabbit Hoxa1 Polyclonal Antibody | anti-Hoxa1 antibody
Mouse Hoxa1 Antibody (Center)
Western Blot (WB)
(Western blot analysis of lysate from mouse lung tissue lysate, using Mouse Hoxa1 Antibody (Center). MBS9210264 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of lysate from mouse lung tissue lysate, using Mouse Hoxa1 Antibody (Center). MBS9210264 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of Hoxa1 (arrow) using rabbit polyclonal Mouse Hoxa1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Hoxa1 gene.)
Western Blot (WB)
(Western blot analysis of Hoxa1 (arrow) using rabbit polyclonal Mouse Hoxa1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Hoxa1 gene.)
Western Blot (WB)
(Mouse Hoxa1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Hoxa1 antibody detected the Hoxa1 protein (arrow).)
Western Blot (WB)
(Mouse Hoxa1 Antibody (Center) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Hoxa1 antibody detected the Hoxa1 protein (arrow).)
The homeobox domain presumably directs sequence-specific DNA binding. The N-terminal portion of ERA-1-993 may be involved in interactions with one or more other regulatory proteins. Such an interaction could regulate either the DNA-binding activity or the transcriptional regulatory activity of ERA-1-993.
The homeoboxless ERA-1-399 protein could act as a competitive inhibitor of the ERA-1-993 protein by competing for interaction with regulatory protein(s) while being unable to bind to DNA.
NCBI and Uniprot Product Information
Uniprot Description
HOXA1: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. Defects in HOXA1 are the cause of Athabaskan brainstem dysgenesis syndrome (ABDS); also known as Narvajo brainstem syndrome. This syndrome is characterized by horizontal gaze palsy, sensorineural deafness, central hypoventilation, and developmental delay. Some patients had swallowing dysfunction, vocal cord paralysis, facial paresis, seizures, and cardiac outflow tract anomalies. Defects in HOXA1 are the cause of Bosley-Salih-Alorainy syndrome (BSAS). Affected individuals show horizontal gaze abnormalities, deafness, facial weakness, vascular malformations of the internal carotid arteries and cardiac outflow trac. Some patients manifest mental retardation and autism spectrum disorder. In contrast to individuals with ABSD, central hypoventilation is not observed in individuals with BSAS. Belongs to the Antp homeobox family. Labial subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; Oncoprotein
Cellular Component: nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding
Biological Process: facial nerve structural organization; central nervous system neuron differentiation; multicellular organismal development; motor axon guidance; rhombomere 4 development; anterior/posterior pattern formation; sensory perception of sound; regulation of transcription, DNA-dependent; optokinetic behavior; anatomical structure formation; embryonic neurocranium morphogenesis; rhombomere 5 development; inner ear development; abducens nerve formation; regulation of behavior; hindbrain development; nervous system development; anatomical structure morphogenesis; inner ear morphogenesis; facial nucleus development; transcription, DNA-dependent; neuromuscular process; outer ear morphogenesis; regulation of transcription from RNA polymerase II promoter; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; cognition; rhombomere 3 development
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Product Notes
The Hoxa1 hoxa1 (Catalog #AAA9210264) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 191-219. The Mouse Hoxa1 Antibody (Center) reacts with Human, mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Hoxa1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Hoxa1 hoxa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hoxa1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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