Rabbit anti-Human HOOK1 Polyclonal Antibody

HOOK1, ID (HOOK1, Protein Hook homolog 1)

Cat. Num. AAA6000278

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: HOOK1; Polyclonal Antibody; ID (HOOK1; Protein Hook homolog 1); Anti -HOOK1; anti-HOOK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-HOOK1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: HOOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-431 amino acids from the Central region of human HOOK1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HOOK1 Antibody (Center) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the HOOK1 antibody detected the HOOK1 protein (arrow).)

Related Product Information for anti-HOOK1 antibody

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].

Product Categories/Family for anti-HOOK1 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 3005085
• NCBI Official Full Name: hook1 protein
• Protein Family: Protein Hook

Uniprot Description

HOOK1: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Belongs to the hook family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p32.1

Cellular Component: microtubule

Molecular Function: identical protein binding; protein binding; actin binding

Biological Process: protein transport; endosome organization and biogenesis; lysosome organization and biogenesis; early endosome to late endosome transport; multicellular organismal development; endosome to lysosome transport; spermatid development