Goat anti-Human Homeobox D10 Polyclonal Antibody | anti-HOXD10 antibody

Homeobox D10 (HOXD10, HOX4, HOX4D, HOX4E, Hox-4.4, Homeo box 4D, Homeo box D10)

Cat. Num. AAA619043

• Gene Names: HOXD10; HOX4; HOX4D; HOX4E; Hox-4.4
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Homeobox D10; Polyclonal Antibody; Homeobox D10 (HOXD10; HOX4; HOX4D; HOX4E; Hox-4.4; Homeo box 4D; Homeo box D10); Anti -Homeobox D10 (HOXD10; anti-HOXD10 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human HOXD10 at ~37kD. Species sequence homology: mouse, rat, equine, bovine.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-HOXD10 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:32000; Western Blot: 0.2-0.6ug/ml
• Immunogen: Synthetic peptide with sequence PNRSCRIEQPVTQQ, from the internal region of human HOXD10 (NP_002139.2).
• Positive Control: Human Kidney lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Chemiluminescence

(MBS619043 (0.2ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-HOXD10 antibody

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

Product Categories/Family for anti-HOXD10 antibody

Antibodies; Abs to Homeobox (HOX)

NCBI and Uniprot Product Information

• NCBI GI #: 23510366
• NCBI GeneID: 3236
• NCBI Accession #: NP_002139.2
• NCBI GenBank Nucleotide #: NM_002148.3
• UniProt Accession #: P28358; Q6NT10
• Molecular Weight: 38,411 Da
• NCBI Official Full Name: homeobox protein Hox-D10
• NCBI Official Synonym Full Names: homeobox D10
• NCBI Official Symbol: HOXD10
• NCBI Official Synonym Symbols: HOX4; HOX4D; HOX4E; Hox-4.4
• NCBI Protein Information: homeobox protein Hox-D10; homeo box 4D; homeo box D10; OTTHUMP00000163335; homeobox protein Hox-4D; homeobox protein Hox-4E
• UniProt Protein Name: Homeobox protein Hox-D10
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXD10
• UniProt Synonym Gene Names: HOX4D; HOX4E
• UniProt Entry Name: HXD10_HUMAN

NCBI Description

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq]

Uniprot Description

HOXD10: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXD10 are a cause of congenital vertical talus (CVT); also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity. Belongs to the Abd-B homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: hindlimb morphogenesis; skeletal muscle development; transcription, DNA-dependent; adult locomotory behavior; neuromuscular process; spinal cord motor neuron cell fate specification; embryonic skeletal morphogenesis; anterior/posterior pattern formation; peripheral nervous system neuron development; forelimb morphogenesis; single fertilization; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; embryonic limb morphogenesis

Disease: Vertical Talus, Congenital