Rabbit HNRPDL Polyclonal Antibody | anti-HNRPDL antibody

HNRPDL Antibody

Cat. Num. AAA9506447

• Gene Names: HNRNPDL; HNRNP; JKTBP; HNRPDL; JKTBP2; LGMD1G; laAUF1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: HNRPDL; Polyclonal Antibody; HNRPDL Antibody; Heterogeneous nuclear ribonucleoprotein D-like; hnRPD-like protein; hnHNRP-DL; JKT41-binding protein; AU-rich element RNA-binding factor; Protein laAUF1; anti-HNRPDL antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: HNRPDL Antibody detects endogenous levels of total HNRPDL protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 244

• Applicable Applications for anti-HNRPDL antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50~1:100; ELISA: 1:1000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human HNRPDL.
• Immunogen Range: 241-290
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using HNRPDL Antibody. The picture on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 332801090
• NCBI GeneID: 9987
• NCBI Accession #: NP_001193929.1
• NCBI GenBank Nucleotide #: NM_001207000.1
• UniProt Accession #: O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43
• Molecular Weight: 46 kDa
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein D-like isoform b
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein D like
• NCBI Official Symbol: HNRNPDL
• NCBI Official Synonym Symbols: HNRNP; JKTBP; HNRPDL; JKTBP2; LGMD1G; laAUF1
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein D-like
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein D-like
• UniProt Gene Name: HNRNPDL
• UniProt Synonym Gene Names: HNRPDL; JKTBP; hnRNP D-like; hnRNP DL

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]

Uniprot Description

Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.