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Rabbit hnRNP K Polyclonal Antibody | anti-hnRNP-K antibody

hnRNP K Rabbit pAb

Gene Names
HNRNPK; AUKS; CSBP; TUNP; HNRPK
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
Purity
Affinity Chromatography
Synonyms
hnRNP K; Polyclonal Antibody; hnRNP K Rabbit pAb; 65 kDa phosphoprotein; CSBP; TUNP; HNRNPK; HNRPK; DC-stretch binding protein; anti-hnRNP-K antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Sequence Length
464
Applicable Applications for anti-hnRNP-K antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP)
Application Notes
WB: 1:5000-1:10000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:20
Immunogen
A synthesized peptide derived from human hnRNP K
Cellular Localization
Cell Junction, Cell Projection, Cytoplasm, Nucleus, Spliceosome
Preparation and Storage
Store at 4 degree C short term. Store at -20 degree C long term. Avoid freeze/thaw cycle.
Related Product Information for anti-hnRNP-K antibody
Facilitate pre-mRNA processing and transport of mRNA from the nucleus to cytoplasm. hnRNP K contains three unique structural motifs termed KH domains that bind poly(C) DNA and RNA sequences. Intricate architecture enables hnRNP K to facilitate mRNA biosynthesis, transcriptional regulation, and signal transduction. Research studies have shown that cytoplasmic hnRNP K expression is increased in oral squamous cell carcinoma and pancreatic cancer, and may be a potential prognostic factor.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
60kDa
NCBI Official Full Name
heterogeneous nuclear ribonucleoprotein K isoform a
NCBI Official Synonym Full Names
heterogeneous nuclear ribonucleoprotein K
NCBI Official Symbol
HNRNPK
NCBI Official Synonym Symbols
AUKS; CSBP; TUNP; HNRPK
NCBI Protein Information
heterogeneous nuclear ribonucleoprotein K
UniProt Protein Name
Heterogeneous nuclear ribonucleoprotein K
UniProt Gene Name
HNRNPK
UniProt Synonym Gene Names
HNRPK; hnRNP K; TUNP
UniProt Entry Name
HNRPK_HUMAN

NCBI Description

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

hnRNP K: a heterogeneous nuclear ribonucleoprotein (hnRNP). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Two alternatively spliced isoforms have been described.

Protein type: RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 9q21.32-q21.33

Cellular Component: nucleoplasm; cell projection; focal adhesion; membrane; cytoplasm; nuclear chromatin; podosome; nucleus

Molecular Function: protein binding; RNA binding; single-stranded DNA binding

Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; viral reproduction; RNA splicing; positive regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; signal transduction; positive regulation of receptor-mediated endocytosis

Research Articles on hnRNP-K

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Product Notes

The hnRNP-K hnrnpk (Catalog #AAA8542652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The hnRNP K Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's hnRNP K can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP). WB: 1:5000-1:10000 IHC: 1:50-1:200 ICC/IF: 1:50-1:200 IP: 1:20. Researchers should empirically determine the suitability of the hnRNP-K hnrnpk for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "hnRNP K, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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