Western Blot (WB)
(NIH/3T3 cells were subjected to SDS PAGE followed by western blot with MBS7600156 (HMGA2 Antibody) at dilution of 1:1000)
Rabbit anti-Human, Mouse HMGA2 Polyclonal Antibody | anti-HMGA2 antibody
HMGA2 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(NIH/3T3 cells were subjected to SDS PAGE followed by western blot with MBS7600156 (HMGA2 Antibody) at dilution of 1:1000)
Western Blot (WB)
(NIH/3T3 cells were subjected to SDS PAGE followed by western blot with MBS7600156 (HMGA2 Antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: nuclear chromosome; nucleoplasm; nucleus
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; AT DNA binding; DNA bending activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-dependent protein kinase activity; nucleosomal DNA binding; protein binding; SMAD binding; transcription factor binding
Biological Process: base-excision repair; cell division; chondrocyte differentiation; chromosome breakage; chromosome condensation; DNA damage response, detection of DNA damage; epithelial to mesenchymal transition; establishment and/or maintenance of chromatin architecture; fat cell differentiation; heterochromatin formation; mesenchymal cell differentiation; mesodermal cell differentiation; mitosis; mitotic cell cycle G2/M transition DNA damage checkpoint; multicellular organismal development; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of growth; regulation of transcription, DNA-dependent; response to virus; stem cell differentiation; transcription from RNA polymerase II promoter
Disease: Leiomyoma, Uterine
Research Articles on HMGA2
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Product Notes
The HMGA2 hmga2 (Catalog #AAA7600156) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HMGA2 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's HMGA2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). Researchers should empirically determine the suitability of the HMGA2 hmga2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HMGA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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