Testing Data
Rabbit anti-Human HMG2L1 Polyclonal Antibody | anti-HMG2L1 antibody
HMG2L1 polyclonal antibody
Gene Names
HMGXB4; HMG2L1; HMGBCG; THC211630
Reactivity
Human
Applications
ELISA
Synonyms
HMG2L1; Polyclonal Antibody; HMG2L1 polyclonal antibody; HMGXB4; anti-HMG2L1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Form/Format
In PBS with 0.05% (W/V) sodium azide.
Appearance: Colorless liquid
Appearance: Colorless liquid
Sequence Length
601
Applicable Applications for anti-HMG2L1 antibody
ELISA (EIA)
Application Notes
ELISA: 1:1000.
Immunogen
Polyclonal antibody raised in rabbit against human HMG2L1 (High mobility group protein 2-like 1) using two KLH conjugated synthetic peptides containing a sequence from the N-terminal and central region of the protein, respectively.
Positive Control
ELISA: Peptides.
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for anti-HMG2L1 antibody
Polyclonal Antibody to detect HMG2L1 in human samples.
Background: High mobility group (HMG) protein 1 and 2 has been classified by DNA binding preferences and are ubiquitous non-histone components of chromatin. They bind to the minor groove of AT-rich DNA sequences with high affinity. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkB family, ATF-2 and c-Jun to activate transcription. HMG-2L1 (High mobility group protein 2-like 1), also known as HMGBCG, is a member of the HMG chromosomal protein superfamily. It contains a single HMG box DNA binding domain, and therefore does not contain an acidic C-terminal tail. HMG-2L1 is expressed in the nucleus and may play a role in transcriptional regulation.
Background: High mobility group (HMG) protein 1 and 2 has been classified by DNA binding preferences and are ubiquitous non-histone components of chromatin. They bind to the minor groove of AT-rich DNA sequences with high affinity. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFkB family, ATF-2 and c-Jun to activate transcription. HMG-2L1 (High mobility group protein 2-like 1), also known as HMGBCG, is a member of the HMG chromosomal protein superfamily. It contains a single HMG box DNA binding domain, and therefore does not contain an acidic C-terminal tail. HMG-2L1 is expressed in the nucleus and may play a role in transcriptional regulation.
Product Categories/Family for anti-HMG2L1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
65,712 Da
NCBI Official Full Name
HMG domain-containing protein 4
NCBI Official Synonym Full Names
HMG box domain containing 4
NCBI Official Symbol
HMGXB4
NCBI Official Synonym Symbols
HMG2L1; HMGBCG; THC211630
NCBI Protein Information
HMG domain-containing protein 4
UniProt Protein Name
HMG domain-containing protein 4
UniProt Gene Name
HMGXB4
UniProt Synonym Gene Names
HMG2L1; HMGBCG
UniProt Entry Name
HMGX4_HUMAN
NCBI Description
High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]
Uniprot Description
HMG2L1: Negatively regulates Wnt/beta-catenin signaling during development.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 22q13.1
Molecular Function: DNA binding; chromatin binding
Biological Process: chromatin remodeling; negative regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; endosome to lysosome transport
Research Articles on HMG2L1
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Product Notes
The HMG2L1 hmgxb4 (Catalog #AAA840827) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HMG2L1 polyclonal antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HMG2L1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:1000. Researchers should empirically determine the suitability of the HMG2L1 hmgxb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HMG2L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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