Rabbit anti-Human HLA-DMB Polyclonal Antibody | anti-HLA-DMB antibody

HLA-DMB Polyclonal Antibody

Cat. Num. AAA2560547

• Gene Names: HLA-DMB; RING7; D6S221E
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: HLA-DMB; Polyclonal Antibody; HLA-DMB Polyclonal Antibody; class II antigen HLA-DM beta chain; Class II histocompatibility antigen; Class II histocompatibility antigen M beta chain; D6S221E; DMB; HLA class II histocompatibility antigen DM beta chain; HLA-DM histocompatibility type; Beta chain; M beta chain; Major histocompatibility complex class II DM beta; MHC class II antigen DMB; MHC class II antigen HLA DM beta chain; MHC class II HLA DMB; OTTHUMP00000029257; Really interesting new gene 7 protein; RING 7; RING7; anti-HLA-DMB antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.96mg/mL (varies by lot)
• Sequence Length: 263

• Applicable Applications for anti-HLA-DMB antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:20-1:100; ELISA: 1:5000-1:10000
• Immunogen: Fusion protein of human HLA-DMB
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using HLA-DMB Polyclonal Antibody at dilution of 1:30(×200))

Related Product Information for anti-HLA-DMB antibody

HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Product Categories/Family for anti-HLA-DMB antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 133160
• NCBI GeneID: 3109
• UniProt Accession #: P28068
• NCBI Official Full Name: HLA class II histocompatibility antigen, DM beta chain
• NCBI Official Synonym Full Names: major histocompatibility complex, class II, DM beta
• NCBI Official Symbol: HLA-DMB
• NCBI Official Synonym Symbols: RING7; D6S221E
• NCBI Protein Information: HLA class II histocompatibility antigen, DM beta chain
• UniProt Protein Name: HLA class II histocompatibility antigen, DM beta chain
• Protein Family: HLA class II histocompatibility antigen
• UniProt Gene Name: HLA-DMB
• UniProt Synonym Gene Names: DMB; RING7
• UniProt Entry Name: DMB_HUMAN

NCBI Description

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Uniprot Description

HLA-DMB: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Belongs to the MHC class II family.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: lysosomal membrane; late endosome membrane; integral to membrane; MHC class II protein complex

Biological Process: peptide antigen assembly with MHC class II protein complex; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell proliferation; immune response; MHC class II protein complex assembly