Rabbit HELO1 / ELOVL5 Polyclonal Antibody | anti-HELO1 antibody

Rabbit Polyclonal to Human HELO1 / ELOVL5

Cat. Num. AAA247480

• Gene Names: ELOVL5; HELO1; SCA38; dJ483K16.1
• Reactivity: Gibbon, Gorilla, Human, Orangutan; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: HELO1 / ELOVL5; Polyclonal Antibody; Rabbit Polyclonal to Human HELO1 / ELOVL5; Anti-HELO1 / ELOVL5 Antibody (C-Terminus) IHC-plus; ELOVL5; ELOVL FA elongase 5; ELOVL fatty acid elongase 5; Fatty acid elongase 1; RP3-483K16.1; DJ483K16.1; HELO1; Human HELO1; anti-HELO1 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Orangutan; Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human ELOVL5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 299

• Applicable Applications for anti-HELO1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (15 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 15 amino acid peptide from C-Terminus of human ELOVL5. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset, Panda (93%); Goat, Dog, Bat, Bovine, Rabbit, Opossum (87%); Elephant
• Immunogen Type: Synthetic peptide
• Immunogen: HELO1 / ELOVL5 antibody was raised against synthetic 15 amino acid peptide from C-Terminus of human ELOVL5. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset, Panda (93%); Goat, Dog, Bat, Bovine, Rabbit, Opossum (87%); Elephant, Horse, Turkey, Chicken, Lizard (80%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-ELOVL5 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-ELOVL5 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

NCBI and Uniprot Product Information

• NCBI GI #: 11464975
• NCBI GeneID: 60481
• NCBI Accession #: NP_068586.1
• NCBI GenBank Nucleotide #: NM_021814.4
• UniProt Accession #: Q9NYP7; Q59EL3; Q5TGH5; Q6NXE7; Q7L2S5; Q8NCG4; Q9UI22; B4DZJ2; F6SH78
• Molecular Weight: 9,580 Da
• NCBI Official Full Name: elongation of very long chain fatty acids protein 5 isoform 1
• NCBI Official Synonym Full Names: ELOVL fatty acid elongase 5
• NCBI Official Symbol: ELOVL5
• NCBI Official Synonym Symbols: HELO1; SCA38; dJ483K16.1
• NCBI Protein Information: elongation of very long chain fatty acids protein 5; ELOVL FA elongase 5; fatty acid elongase 1; spinocerebellar ataxia 38; 3-keto acyl-CoA synthase ELOVL5; very-long-chain 3-oxoacyl-CoA synthase 5; homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2; ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
• UniProt Protein Name: Elongation of very long chain fatty acids protein 5
• UniProt Gene Name: ELOVL5
• UniProt Synonym Gene Names: ELOVL2; ELOVL FA elongase 5; hELO1
• UniProt Entry Name: ELOV5_HUMAN

NCBI Description

This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

ELOVL5: Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. Belongs to the ELO family.

Protein type: Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; EC 2.3.1.199

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: endoplasmic reticulum membrane; cell soma; membrane; endoplasmic reticulum; dendrite; integral to membrane

Molecular Function: protein binding; fatty acid elongase activity

Biological Process: unsaturated fatty acid metabolic process; very-long-chain fatty acid biosynthetic process; linoleic acid metabolic process; triacylglycerol biosynthetic process; unsaturated fatty acid biosynthetic process; cellular lipid metabolic process

Disease: Spinocerebellar Ataxia 38