Western Blot (WB)
(Anti- HDAC11 Picoband antibody, MBS177658, Western blottingAll lanes: Anti HDAC11 (MBS177658) at 0.5ug/mlLane 1: Rat Skeletal Muscle Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Cardiac Muscle Tissue Lysate at 50ugLane 4: NRK Whole Cell Lysate at 40ugLane 5: 293T Whole Cell Lysate at 40ugLane 6: HELA Whole Cell Lysate at 40ugLane 7: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD )
HDAC11 Polyclonal Antibody | anti-HDAC11 antibody
Anti-HDAC11 Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- HDAC11 Picoband antibody, MBS177658, Western blottingAll lanes: Anti HDAC11 (MBS177658) at 0.5ug/mlLane 1: Rat Skeletal Muscle Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Cardiac Muscle Tissue Lysate at 50ugLane 4: NRK Whole Cell Lysate at 40ugLane 5: 293T Whole Cell Lysate at 40ugLane 6: HELA Whole Cell Lysate at 40ugLane 7: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD )
Western Blot (WB)
(Anti- HDAC11 Picoband antibody, MBS177658, Western blottingAll lanes: Anti HDAC11 (MBS177658) at 0.5ug/mlLane 1: Rat Skeletal Muscle Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Cardiac Muscle Tissue Lysate at 50ugLane 4: NRK Whole Cell Lysate at 40ugLane 5: 293T Whole Cell Lysate at 40ugLane 6: HELA Whole Cell Lysate at 40ugLane 7: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD )
Immunohistochemistry (IHC)
(Anti- HDAC11 Picoband antibody, MBS177658,IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti- HDAC11 Picoband antibody, MBS177658,IHC(P)IHC(P): Mouse Brain Tissue )
Immunohistochemistry (IHC)
(Anti- HDAC11 Picoband antibody, MBS177658,IHC(P)IHC(P): Rat Brain Tissue )
Immunohistochemistry (IHC)
(Anti- HDAC11 Picoband antibody, MBS177658,IHC(P)IHC(P): Rat Brain Tissue )
Background: Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This gene encodes a class IV histone deacetylase. And the encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. In addition, HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
Uniprot Description
HDAC11: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Deacetylase; EC 3.5.1.98
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: histone deacetylase complex; nucleus; plasma membrane
Molecular Function: histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); transcription factor binding
Biological Process: chromatin modification; histone deacetylation; oligodendrocyte development; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on HDAC11
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Product Notes
The HDAC11 hdac11 (Catalog #AAA177658) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-HDAC11 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HDAC11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the HDAC11 hdac11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HDAC11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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