Rabbit HDAC 10 Polyclonal Antibody | anti-HDAC10 antibody

HDAC 10 (E24) Polyclonal Antibody

Cat. Num. AAA3000578

• Gene Names: HDAC10; HD10
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: HDAC 10; Polyclonal Antibody; HDAC 10 (E24) Polyclonal Antibody; Histone deacetylase 10; HD10; HDAC10; anti-HDAC10 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: HDAC10 (E24) polyclonal antibody detects endogenous levels of HDAC10 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 649

• Applicable Applications for anti-HDAC10 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to the N-terminal of Human HDAC 10.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of HDAC 10 (E24) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.)

Related Product Information for anti-HDAC10 antibody

There are 11 members in the HDAC family that are divided into four classes. Class I HDACs represent homologs of the yeast histone deacetylase Rpd3, class II HDACs share strong homology with the yeast histone deacetylase Hda1, class III HDACs are closely related to the yeast Sir2 protein and class IV HDACs comprise histone deacetylase 11 (HDAC11)-related enzymes. HDAC10, also known as HD10, is a member of the class II HDACs. It contains an N-terminal Hda1p-related catalytic domain and a unique C-terminal leucine-rich domain. HDAC10 is ubiquitously expressed and can shuttle between the cytoplasm and nucleus in response to celllular signals.

NCBI and Uniprot Product Information

• NCBI GI #: 226529806
• NCBI GeneID: 83933
• NCBI Accession #: NP_001152758.1
• NCBI GenBank Nucleotide #: NP_001152758.1
• UniProt Accession #: Q969S8
• Molecular Weight: ~ 75kDa
• NCBI Official Full Name: polyamine deacetylase HDAC10 isoform 2
• NCBI Official Synonym Full Names: histone deacetylase 10
• NCBI Official Symbol: HDAC10
• NCBI Official Synonym Symbols: HD10
• NCBI Protein Information: polyamine deacetylase HDAC10
• UniProt Protein Name: Histone deacetylase 10
• Protein Family: Histone deacetylase
• UniProt Gene Name: HDAC10
• UniProt Synonym Gene Names: HD10
• UniProt Entry Name: HDA10_HUMAN

NCBI Description

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

HDAC10: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Belongs to the histone deacetylase family. HD type 2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Deacetylase; EC 3.5.1.98; Transcription factor

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nucleus

Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); enzyme binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity

Biological Process: Notch signaling pathway; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; protein amino acid deacetylation; regulation of transcription, DNA-dependent; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; oligodendrocyte development; negative regulation of transcription, DNA-dependent