Rabbit anti-Human, Mouse HBS1L Polyclonal Antibody | anti-HBS1L antibody

HBS1L, ID (HBS1L, HBS1, KIAA1038, HBS1-like protein, ERFS) (FITC)

Cat. Num. AAA6305639

• Gene Names: HBS1L; ERFS; HBS1; EF-1a; eRF3c; HSPC276
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HBS1L; Polyclonal Antibody; ID (HBS1L; HBS1; KIAA1038; HBS1-like protein; ERFS) (FITC); ERFS; anti-HBS1L antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-HBS1L antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HBS1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 459-486 amino acids from the Central region of human HBS1L.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HBS1L Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the HBS1L antibody detected the HBS1L protein (arrow).)

Related Product Information for anti-HBS1L antibody

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Product Categories/Family for anti-HBS1L antibody

Antibodies; KIAA; orf

References

Nuinoon, M., et al. Hum. Genet. 127(3):303-314(2010). Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010). Nuinoon, M., et al. Hum. Genet. (2009). In press: Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009). Ferreira, M.A., et al. Am. J. Hum. Genet. 85(5):745-749(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 223555963
• NCBI GeneID: 10767
• NCBI Accession #: NP_001138630.1
• NCBI GenBank Nucleotide #: NM_001145158.1
• UniProt Accession #: Q9Y450; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; B7Z365
• Molecular Weight: 75,473 Da
• NCBI Official Full Name: HBS1-like protein isoform 2
• NCBI Official Synonym Full Names: HBS1-like translational GTPase
• NCBI Official Symbol: HBS1L
• NCBI Official Synonym Symbols: ERFS; HBS1; EF-1a; eRF3c; HSPC276
• NCBI Protein Information: HBS1-like protein; eRF3 family member; ERF3-similar protein; Hsp70 subfamily B suppressor 1-like protein
• UniProt Protein Name: HBS1-like protein
• Protein Family: HBS1-like protein
• UniProt Gene Name: HBS1L
• UniProt Synonym Gene Names: HBS1; KIAA1038
• UniProt Entry Name: HBS1L_HUMAN

Uniprot Description

HBS1: a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]

Protein type: Translation elongation; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: membrane

Molecular Function: GTPase activity; GTP binding; translation elongation factor activity

Biological Process: translational elongation; translation; signal transduction